Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond.
Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond.
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基于光的抗感染物：紫外线C辐射，光动力疗法，蓝光等。
DOI：
10.1016/j.coph.2013.08.009
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发表时间：
2013-10
影响因子：
4
通讯作者：
Hamblin, Michael R.
中科院分区：
文献类型：
--
作者：
Yin, Rui;Dai, Tianhong;Avci, Pinar;Serafim Jorge, Ana Elisa;de Melo, Wanessa C. M. A.;Vecchio, Daniela;Huang, Ying-Ying;Gupta, Asheesh;Hamblin, Michael R.
由于世界范围内抗生素耐药性的增加，研究人员正在研究替代的抗感染策略，认为微生物将无法产生耐药性。在这些策略中，突出的是一组依赖于光来提供致命打击的方法。众所周知，紫外线，特别是UVC（200- 280 nm），是杀菌的，但直到最近才被开发为抗感染方法，当时人们意识到，与其杀死病原体的高活性相比，对宿主组织可能的不利影响相对较小。光动力疗法是无毒光敏染料与无害可见光的组合，它们一起产生大量的破坏性活性氧（ROS）。某些阳离子染料或光敏剂具有良好的结合微生物细胞的特异性，同时保留宿主哺乳动物细胞，并且可以用于通过使用光纤递送的光治疗许多局部感染，包括浅表的甚至是深层的。许多微生物细胞对蓝光（400-470 nm）的杀伤高度敏感，这是由于自然产生的光敏剂如卟啉和黄素的积累。近红外光也被证明对某些物种具有抗菌作用。这些技术的临床应用包括皮肤、牙齿、伤口、胃、鼻、脚趾甲和其他感染，这些感染适合于有效的光递送。
Owing to the worldwide increase in antibiotic resistance, researchers are investigating alternative anti-infective strategies to which it is supposed microorganisms will be unable to develop resistance. Prominent among these strategies, is a group of approaches which rely on light to deliver the killing blow. As is well known, ultraviolet light, particularly UVC (200–280nm), is germicidal, but it has not been much developed as an anti-infective approach until recently, when it was realized that the possible adverse effects to host tissue were relatively minor compared to its high activity in killing pathogens. Photodynamic therapy is the combination of non-toxic photosensitizing dyes with harmless visible light that together produce abundant destructive reactive oxygen species (ROS). Certain cationic dyes or photosensitizers have good specificity for binding to microbial cells while sparing host mammalian cells and can be used for treating many localized infections, both superficial and even deep-seated by using fiber optic delivered light. Many microbial cells are highly sensitive to killing by blue light (400–470 nm) due to accumulation of naturally occurring photosensitizers such as porphyrins and flavins. Near infrared light has also been shown to have antimicrobial effects against certain species. Clinical applications of these technologies include skin, dental, wound, stomach, nasal, toenail and other infections which are amenable to effective light delivery.
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通过阳离子中二取代的卟啉对革兰氏阴性和革兰氏阳性细菌的光活化的电荷效应。
影响因子：
4.2
作者：
Alves E;Costa L;Carvalho CM;Tomé JP;Faustino MA;Neves MG;Tomé AC;Cavaleiro JA;Cunha A;Almeida A
通讯作者：
Almeida A
DOI：
10.1007/978-1-60761-697-9_13
发表时间：
2010-01-01
期刊：
PHOTODYNAMIC THERAPY: METHODS AND PROTOCOLS
影响因子：
--
作者：
Biel, Merrill A.
通讯作者：
Biel, Merrill A.
影响因子：
3.6
作者：
Akilov, Oleg E.;Kosaka, Sachiko;Hasan, Tayyaba
通讯作者：
Hasan, Tayyaba
影响因子：
2.7
作者：
Alcántara-Díaz, D;Breña-Valle, M;Serment-Guerrero, J
通讯作者：
Serment-Guerrero, J
DOI：
10.1007/s10295-008-0446-2
发表时间：
2008-11-01
影响因子：
3.4
作者：
Alves, Eliana;Carvalho, Carla M. B.;Almeida, Adelaide
通讯作者：
Almeida, Adelaide