Design of a Multicompartment Hydrogel that Facilitates Time-Resolved Delivery of Combination Therapy and Synergized Killing of Glioblastoma.
Design of a Multicompartment Hydrogel that Facilitates Time-Resolved Delivery of Combination Therapy and Synergized Killing of Glioblastoma.
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DOI：
10.1002/anie.201806483
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发表时间：
2018-11-12
期刊：
影响因子：
--
通讯作者：
Schneider JP
中科院分区：
文献类型：
--
作者：
Majumder P;Baxa U;Walsh STR;Schneider JP
目前对鉴定协同作用以治疗疾病的新的组合疗法存在显著的兴趣，并且越来越清楚的是，它们的施用的时间分辨率极大地影响功效。为了促进有效递送，我们开发了一种多隔室水凝胶材料，其由在物理交联原纤维的自组装肽基网络内交织的球形囊泡组成，所述物理交联原纤维允许小分子的时间分辨独立共递送。在本文中，我们证明了这种材料结构以ERL→DOX顺序方式有效地递送EGFR激酶抑制剂厄洛替尼（ERL）和多柔比星（DOX，DNA嵌入剂），以协同杀死胶质母细胞瘤，这是最具侵袭性的脑癌形式。分裂的我们：通过可注射多室水凝胶材料实现的小分子药物的时间分辨递送强烈协同其在胶质母细胞瘤中的凋亡活性
There is significant current interest in identifying new combination therapies that synergize to treat disease, and it is becoming increasingly clear that the temporal resolution of their administration greatly impacts efficacy. To facilitate effective delivery, we developed a multicompartment hydrogel material composed of spherical vesicles interlaced within a self-assembled peptide-based network of physically crosslinked fibrils that allows time-resolved independent co-delivery of small molecules. Herein, we demonstrate that this material architecture effectively delivers the EGFR kinase inhibitor erlotinib (ERL) and doxorubicin (DOX, DNA intercalator) in an ERL→DOX sequential manner to synergistically kill glioblastoma, the most aggressive form of brain cancer. Divided We Stand: Time-resolved delivery of small molecule drugs achieved via an injectable multicompartment hydrogel material strongly synergizes their apoptotic activity in Glioblastoma
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影响因子：
14
作者：
Branco, Monica C.;Pochan, Darrin J.;Wagner, Norman J.;Schneider, Joel P.
通讯作者：
Schneider, Joel P.
DOI：
10.1073/pnas.73.5.1603
发表时间：
1976-01-01
影响因子：
11.1
作者：
POSTE, G;PAPAHADJOPOULOS, D
通讯作者：
PAPAHADJOPOULOS, D
DOI：
10.1073/pnas.0701980104
发表时间：
2007-05-08
影响因子：
11.1
作者：
Haines-Butterick, Lisa;Rajagopal, Karthikan;Schneider, Joel P.
通讯作者：
Schneider, Joel P.
影响因子：
7.4
作者：
Li Y;Wang F;Cui H
通讯作者：
Cui H
影响因子：
6.2
作者：
Rajagopal, Karthikan;Lamm, Matthew S.;Schneider, Joel P.
通讯作者：
Schneider, Joel P.