Peptide-Based Supramolecular Hydrogels for Delivery of Biologics.
Peptide-Based Supramolecular Hydrogels for Delivery of Biologics.
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DOI：
10.1002/btm2.10041
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发表时间：
2016-09
影响因子：
7.4
通讯作者：
Cui H
中科院分区：
文献类型：
--
作者：
Li Y;Wang F;Cui H
近几十年来，对治疗性生物制剂的需求迅速增长，制药行业从小分子药物到生物大分子治疗药物发生了巨大转变。由于它们的大尺寸和先天的不稳定性，生物药物的全身、局部和局部递送仍然是一项极具挑战性的任务。尽管存在许多类型的递送载体，肽和肽偶联物由于其固有的生物相容性、可调节的生物降解性和对各种生物刺激的反应性，作为分子块，创造了多种超分子纳米结构和水凝胶，用于有效递送生物制剂，已受到越来越多的关注。在此背景下，我们讨论了以小分子肽和肽偶联物为分子构建单元的超分子水凝胶的设计原理，并综述了近年来利用这些材料进行蛋白质和基因传递的研究进展。
The demand for therapeutic biologics has rapidly grown over recent decades, creating a dramatic shift in the pharmaceutical industry from small molecule drugs to biological macromolecular therapeutics. As a result of their large size and innate instability, the systemic, topical, and local delivery of biologic drugs remains a highly challenging task. Although there exist many types of delivery vehicles, peptides and peptide conjugates have received continuously increasing interest as molecular blocks to create a great diversity of supramolecular nanostructures and hydrogels for the effective delivery of biologics, due to their inherent biocompatibility, tunable biodegradability, and responsiveness to various biological stimuli. In this context, we discuss the design principles of supramolecular hydrogels using small molecule peptides and peptide conjugates as molecular building units, and review the recent effort in using these materials for protein delivery and gene delivery.
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