Neuropeptide-Y Family of Peptides in the Autocrine-Paracrine Regulation of Adrenocortical Function
Neuropeptide-Y Family of Peptides in the Autocrine-Paracrine Regulation of Adrenocortical Function
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神经肽-Y 家族肽在肾上腺皮质功能自分泌-旁分泌调节中的作用
DOI：
10.1055/s-2007-978900
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发表时间：
1998
影响因子：
2.2
通讯作者：
G. Gottardo
中科院分区：
文献类型：
--
作者：
Nussdorfer Gg;G. Gottardo
神经肽-Y (NPY)、肽 YY (PYY) 和胰多肽 (PP) 是 36 个氨基酸肽家族，广泛分布于体内，并通过 G 蛋白偶联 Y 受体的几种亚型发挥作用。 NPY 家族肽的三个成员包含在肾上腺中，发挥各种自分泌/旁分泌调节功能。 NPY 的结合位点存在于肾上腺髓质和肾小球带 (ZG) 中，其中还有一些 NPY 能纤维的末端。 PYY 和 PP 的结合位点主要位于肾上腺皮质内区和肾上腺髓质。 NPY 和 PYY 抑制分散的 ZG 细胞的醛固酮分泌，但这种作用可能被认为是非特异性的且本质上有毒。相反，有迹象表明 NPY 可能通过引发儿茶酚胺的释放来间接刺激 ZG 细胞，从而增强醛固酮的分泌。还有证据表明 NPY 调节 ZG 细胞对其主要激动剂的分泌反应。 PP能够提高糖皮质激素的分泌，直接作用于内肾上腺皮质细胞。 NPY 家族肽的这些作用的生理相关性仍有待通过未来使用更具选择性的 Y 受体激动剂和拮抗剂的实验研究来解决。相比之下，间接证据表明内源性 NPY 家族肽可能在衰老、低血糖应激和嗜铬细胞瘤等超生理或病理条件下的肾上腺皮质分泌作用调节中发挥重要作用。
Neuropeptide-Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP) are a family of 36-amino-acid peptides, which are widely distributed in the body and act through several subtypes of G-protein-coupled Y receptors. The three members of the NPY-family peptides are contained in the adrenal gland, where they exert various autocrine/paracrine regulatory functions. Binding sites for NPY are present in adrenal medulla and zona glomerulosa (ZG), where also several NPY-ergic fibers end. Binding sites for PYY and PP are prevalently located in the inner adrenocortical zones and adrenal medulla. NPY and PYY inhibit aldosterone secretion of dispersed ZG cells, but this effect has probably to be considered nonspecific and toxic in nature. On the contrary, there are indications that NPY may indirectly stimulate ZG cells, by eliciting the release of catecholamines, which in turn enhance aldosterone secretion. Evidence is also available that NPY modulates the secretory response of ZG cells to their main agonists. PP is able to raise glucocorticoid secretion acting directly on the inner adrenocortical cells. The physiological relevance of these effects of NPY-family peptides remains to be addressed by future experimental studies employing more selective Y receptor agonists and antagonists. In contrast, indirect evidence is available that endogenous NPY-family peptides might play an important role in the modulation of adrenocortical secretory action under paraphysiological or pathological conditions such as like aging, hypoglycemic stress and pheochromocytomas.
影响因子：
--
作者：
WHITCOMB, DC;VIGNA, SR;TAYLOR, IL
通讯作者：
TAYLOR, IL
DOI：
10.1146/annurev.pa.33.040193.001521
发表时间：
1993
影响因子：
12.5
作者：
Claes Wahlestedt;Donald J. Reis
通讯作者：
Claes Wahlestedt;Donald J. Reis
分化对神经肽 Y 受体和大鼠嗜铬细胞瘤细胞反应的影响。
影响因子：
4.8
作者：
DiMaggio,DA;FarahJr,JM;Westfall,TC
通讯作者：
Westfall,TC