Teaching Crystallography by Determining Small Molecule Structures and 3-D Printing: An Inorganic Chemistry Laboratory Module
Teaching Crystallography by Determining Small Molecule Structures and 3-D Printing: An Inorganic Chemistry Laboratory Module
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通过确定小分子结构和 3D 打印来教授晶体学：无机化学实验室模块
DOI：
10.1021/acs.jchemed.0c00206
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发表时间：
2020
影响因子：
3
通讯作者：
Stieber, S. Chantal
中科院分区：
文献类型：
--
作者：
Brannon, Jacob P.;Ramirez, Isaac;Williams, DaShawn;Barding, Gregory A.;Liu, Yan;McCulloch, Kathryn M.;Chandrasekaran, Perumalreddy;Stieber, S. Chantal
用于确定 3-D 原子结构的实验方法（例如晶体学）很少在本科课程中教授，但被认为是研究环境中 3-D 结构确定的规范。尽管对晶体学的完全物理理解需要多年的实践，但小分子晶体学的实际应用和基本解释可以很容易地融入本科课程中，为学生提供类似研究的实验室体验。使用免费的 Olex2 软件开发了三个 1-h 晶体学实验室模块，以确定 (二硫醇)2Co(1,3,5-三氮杂-7-磷金刚烷)·二氯乙烷的结构，同时介绍基本晶体学知识、通过显微镜进行晶体评估、实用结构测定技能以及通过 3D 打印进行空间感知。在由 14 名硕士和本科生组成的高级仪器分析课程中实施后，根据定制的评估调查，小分子晶体学的主题知识增加了 18-30%，学生的反馈非常积极。这表明没有晶体学背景的学生能够从这些实验室模块中学习并保留有关小分子晶体学的信息。
Experimental methods for determining 3-D atomic structures, such as crystallography, are rarely taught in the undergraduate curriculum, yet are considered to be the norm for 3-D structure determination in a research setting. Although a fully physical understanding of crystallography takes years of practice, practical applications and basic interpretation of small-molecule crystallography can be readily integrated into undergraduate curricula to give students a research-like laboratory experience. Three 1-h crystallography laboratory modules were developed using the free Olex2software to determine the structure of (dithiolene)2Co(1,3,5-triaza-7-phosphaadamantane)·dichloroethane, while introducing basic crystallography knowledge, crystal evaluation through microscopy, practical structure determination skills, and spatial awareness through 3-D printing. Following implementation in an advanced instrumental analysis class composed of 14 Master’s and undergraduate students, the increase of topical knowledge of small molecule crystallography was 18–30% based on tailored assessment surveys, and student feedback was highly positive. This suggests that students without a prior background in crystallography were able to learn and retain information about small molecule crystallography from these laboratory modules.
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DOI：
--
发表时间：
2008
期刊：
影响因子：
--
作者：
Stephanie A. Bossé;N. Loening
通讯作者：
N. Loening
影响因子：
3
作者：
Casas, Lluis;Estop, Eugenia
通讯作者：
Estop, Eugenia
理解结构：基于计算机的高分子生物化学实验室活动
影响因子：
3
作者：
K. McLaughlin
通讯作者：
K. McLaughlin
课堂外教学：化学学生晶体学教育实地考察
影响因子：
3
作者：
Brian J. Malbrecht;Michael G. Campbell;Yu;Shao
通讯作者：
Shao
影响因子：
3
作者：
Scalfani, Vincent F.;Vaid, Thomas P.
通讯作者：
Vaid, Thomas P.