Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women: the JACC study.
Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women: the JACC study.
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DOI：
10.2188/jea.16.177
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发表时间：
2006-09
影响因子：
4.7
通讯作者：
JACC Study Group
中科院分区：
文献类型：
--
作者：
Cui R;Iso H;Toyoshima H;Date C;Yamamoto A;Kikuchi S;Kondo T;Watanabe Y;Koizumi A;Inaba Y;Tamakoshi A;JACC Study Group
白种人妇女过早绝经与冠心病风险增加有关。然而，这种关联尚未在亚洲女性中得到检验。我们在日本协同队列（JACC）研究中对37,965名40-79岁的日本绝经后妇女进行了一项为期10年的队列研究。死亡原因是根据国际疾病分类确定的。中风死亡487例，冠心病死亡178例。初潮晚或绝经早，或生殖期短与冠心病死亡风险无关。然而，与初潮年龄≤13岁的女性相比，初潮年龄≥17岁的女性卒中死亡风险增加：多变量风险比为1.32（95%可信区间[CI]: 0.93-1.87, p = 0.10）。与绝经年龄≥49岁的妇女相比，绝经年龄<49岁的妇女在40-64岁妇女中患冠心病的风险增加；多变量风险比为1.85 （95% CI: 0.92 ~ 3.73, p = 0.08）。中年妇女早期绝经与冠心病之间的可能关联与对高加索妇女的观察性研究结果一致，并且可以通过内源性雌激素对动脉粥样硬化发展的保护作用来解释。
Early menopause is associated with increased risk of coronary heart disease in Caucasian women. However, this association has not been examined in Asian women. We conducted a 10-year cohort study of 37,965 Japanese post-menopausal women aged 40-79 years in the Japan Collaborative Cohort (JACC) Study. Causes of death were determined based on the International Classification of Disease. There were 487 mortality of stroke and 178 mortality of coronary heart disease. Late menarche or early menopause, or shorter duration of reproductive period was not associated with risk of mortality from coronary heart disease. However, compared with women with age at menarche ≤13 years, those with age at menarche ≥17 years tended to have increased risk of mortality from stroke: the multivariable hazard ratio was 1.32 (95% confidence interval [CI]: 0.93-1.87, p = 0.10). Compared with women with age at menopause of ≥49 years, those with age at menopause of <49 years tended to have increased risk of coronary heart disease among women aged 40-64 years; the multivariable hazard ratio was 1.85 (95% CI: 0.92-3.73, p = 0.08). The possible association between early menopause and coronary heart disease among middle-aged women was consistent with the result of observational studies for Caucasian women, and can be explained by a protective effect of endogenous estrogen on the development of atherosclerosis.
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影响因子：
5.1
作者：
Fujino, Y;Tamakoshi, A;Yoshimura, T
通讯作者：
Yoshimura, T
DOI：
10.1111/j.1471-0528.1992.tb14414.x
发表时间：
1992-10-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
FALKEBORN, M;PERSSON, I;NAESSEN, T
通讯作者：
NAESSEN, T
影响因子：
8.3
作者：
Okamoto, K;Horisawa, R;Ohno, Y
通讯作者：
Ohno, Y
影响因子：
158.5
作者：
STAMPFER, MJ;COLDITZ, GA;HENNEKENS, CH
通讯作者：
HENNEKENS, CH
影响因子：
2.4
作者：
Park, JK;Kim, HJ;Koh, SY
通讯作者：
Koh, SY