Bone defect reconstruction via endochondral ossification: A developmental engineering strategy.
Bone defect reconstruction via endochondral ossification: A developmental engineering strategy.
复制标题
通过软骨内骨化重建骨缺损：一种发展工程策略
DOI：
10.1177/20417314211004211
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发表时间：
2021-01
影响因子：
8.2
通讯作者：
Huang RL
中科院分区：
文献类型：
--
作者：
Fu R;Liu C;Yan Y;Li Q;Huang RL
传统的骨组织工程（BTE）策略通过模拟膜内成骨的胚胎学过程诱导直接骨样基质形成。然而，这些用于骨修复的临床策略的临床转化受到体内植入后有限的血管化和不良的骨再生的阻碍。克服这些缺点的替代策略是通过重现软骨内骨化（ECO）的胚胎过程来工程化软骨构建体;这些构建体已经显示出在缺氧条件下存活以及诱导新血管形成和骨化的独特能力。这种发育工程化的构建体可以作为短暂的仿生模板，以促进关键尺寸缺损中的骨再生。本文介绍了发育性BTE的概念和机制，探讨了软骨内骨移植工程的路线，强调了通过ECO为基础的策略在大骨缺损重建的最新技术水平，并提供了将当前知识从实验室转化到床边的挑战和未来方向的观点。
Traditional bone tissue engineering (BTE) strategies induce direct bone-like matrix formation by mimicking the embryological process of intramembranous ossification. However, the clinical translation of these clinical strategies for bone repair is hampered by limited vascularization and poor bone regeneration after implantation in vivo. An alternative strategy for overcoming these drawbacks is engineering cartilaginous constructs by recapitulating the embryonic processes of endochondral ossification (ECO); these constructs have shown a unique ability to survive under hypoxic conditions as well as induce neovascularization and ossification. Such developmentally engineered constructs can act as transient biomimetic templates to facilitate bone regeneration in critical-sized defects. This review introduces the concept and mechanism of developmental BTE, explores the routes of endochondral bone graft engineering, highlights the current state of the art in large bone defect reconstruction via ECO-based strategies, and offers perspectives on the challenges and future directions of translating current knowledge from the bench to the bedside.
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DOI：
10.1073/pnas.1411975111
发表时间：
2014-12-09
影响因子：
11.1
作者：
Bourgine, Paul E.;Scotti, Celeste;Martin, Ivan
通讯作者：
Martin, Ivan
影响因子：
3.1
作者：
Costales, David Robla;Junquera, Luis;Meana-Infiesta, Alvaro
通讯作者：
Meana-Infiesta, Alvaro
影响因子：
4.1
作者：
Berendsen AD;Olsen BR
通讯作者：
Olsen BR
影响因子：
14
作者：
Bourgine, Paul E.;Pippenger, Benjamin E.;Martin, Ivan
通讯作者：
Martin, Ivan
影响因子：
5.9
作者：
Bolander J;Ji W;Leijten J;Teixeira LM;Bloemen V;Lambrechts D;Chaklader M;Luyten FP
通讯作者：
Luyten FP