A cross-sectional study of general cognitive abilities among Uruguayan school children with low-level arsenic exposure, potential effect modification by methylation capacity and dietary folate.
A cross-sectional study of general cognitive abilities among Uruguayan school children with low-level arsenic exposure, potential effect modification by methylation capacity and dietary folate.
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DOI：
10.1016/j.envres.2018.02.021
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发表时间：
2018-07
影响因子：
8.3
通讯作者：
Kordas K
中科院分区：
文献类型：
--
作者：
Desai G;Barg G;Queirolo EI;Vahter M;Peregalli F;Mañay N;Kordas K
很少有研究评估低水平砷（As）暴露与儿童认知能力之间的关系。在这项横断面研究中，我们评估了蒙得维的亚5-8岁儿童的低水平As暴露和认知能力之间的关联，并测试了As甲基化能力和儿童膳食叶酸摄入量的影响。本文测定了328例儿童尿中总砷（UAs）浓度和尿中甲基胂酸（MMA）的比例。使用标准化Woodcock-Muñoz认知成套测验的7个分测验评估认知表现，并由此得出一般智力能力（GIA）评分。总叶酸摄入量是根据两次24小时饮食回忆来估计的。进行线性回归分析。通过在中位数%MMA值和总叶酸摄入量的三分位数（计算为膳食叶酸当量（dfe）的微克（μg））进行分层来评估效应改变。中位UA为11.9 μg/l（范围= 1.4-93.9），平均叶酸摄入量为337.4（SD=123.3）μg dfe，中位%MMA为9.42（范围=2.6-24.8）。UA和认知能力之间没有关联，并且%MMA没有一致的效果修改。不饱和脂肪酸与概念形成呈负相关，与认知效率呈正相关，在叶酸摄入量最低的三分位数中，数字颠倒子测试;不饱和脂肪酸还与叶酸摄入量最高的三分位数中的第二个三分位数和概念形成中的声音整合呈正相关。MMA或叶酸摄入量对效应的影响没有一致的模式。结论：低水平砷暴露与一般认知能力无相关性。
Few studies have evaluated the association between low-level arsenic (As) exposure and cognitive performance among children. In this cross-sectional study, we assessed the association between low-level As exposure and cognitive performance among 5–8 year-old children in Montevideo, and tested effect modification by As methylation capacity and children’s dietary folate intake. We measured total urinary As (UAs) concentrations and the proportion of monomethylarsonic acid (MMA) in the urine of 328 children. Seven subtests of the standardized Woodcock-Muñoz cognitive battery were used to assess cognitive performance, from which, the general intellectual abilities (GIA) score was derived. Total folate intake was estimated from two 24-hour dietary recalls. Linear regression analyses were performed. Effect modification was assessed by stratifying at the median %MMA value and tertiles of total folate intake calculated as micrograms (μg) of dietary folate equivalents (dfe). The median UAs was 11.9 μg/l (range = 1.4–93.9), mean folate intake was 337.4 (SD=123.3) μg dfe, and median %MMA was 9.42 (range=2.6–24.8). There was no association between UAs and cognitive abilities, and no consistent effect modification by %MMA. UAs was associated inversely with concept formation, and positively with cognitive efficiency and numbers reversed subtest in the lowest folate intake tertile; UAs was also positively associated with sound integration in the second tertile and concept formation in the highest tertile of folate intake. There was no consistent pattern of effect modification by %MMA or folate intake. Conclusion: There was no association between low-level As exposure and general cognitive abilities.
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