Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis.
Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis.
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DOI：
10.1155/2016/6940480
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发表时间：
2016
影响因子：
4.6
通讯作者：
Cai H
中科院分区：
文献类型：
--
作者：
Cao M;Swigris JJ;Wang X;Cao M;Qiu Y;Huang M;Xiao Y;Cai H
背景特发性肺纤维化（IPF）的自然史非常复杂且不可预测。部分患者会出现急性加重（AE）和致死性结局。方法.该研究包括30例AE-IPF患者、32例稳定型IPF（S-IPF）患者和12例健康对照。我们测量了瘦素和KL-6的血浆浓度。简单相关被用来评估瘦素和其他变量之间的关联。比较AE-IPF和S-IPF受试者、死亡者和存活者的血浆瘦素水平。Kaplan-Meier曲线用于显示生存率，考克斯比例风险回归用于检查生存率的风险因素。结果在AE-IPF受试者中，血浆瘦素显著高于S-IPF受试者（p = 0.0003）或健康对照受试者（p < 0.0001）。血浆瘦素与BMI、KL-6、LDH、CRP和PaO 2/FiO 2相关（分别为p = 0.007、p = 0.005、p = 0.003、p = 0.033和p = 0.032）。33例死亡者的血浆瘦素水平显著高于23例存活者（p = 0.007）。多变量考克斯回归分析显示瘦素（>13.79 ng/mL）是生存的独立预测因子（p = 0.004）。结论.瘦素可能是AE-IPF发生的一种有前景的血浆生物标志物，并可预测IPF患者的生存率。
Background. The natural history of idiopathic pulmonary fibrosis (IPF) is very complex and unpredictable. Some patients will experience acute exacerbation (AE) and fatal outcomes. Methods. The study included 30 AE-IPF patients, 32 stable IPF (S-IPF) patients, and 12 healthy controls. We measured the plasma concentrations of leptin and KL-6. Simple correlation was used to assess associations between leptin and other variables. Plasma leptin levels were compared between AE-IPF and S-IPF subjects, decedents, and survivors. Kaplan-Meier curves were used to display survival and Cox proportional hazards regression was used to examine risk factors for survival. Results. In subjects with AE-IPF, plasma leptin was significantly greater than in subjects with S-IPF (p = 0.0003) or healthy controls (p < 0.0001). Plasma leptin was correlated with BMI, KL-6, LDH, CRP, and PaO2/FiO2 (p = 0.007; p = 0.005; p = 0.003; p = 0.033; and p = 0.032, resp.). Plasma leptin was significantly greater in 33 decedents than in the 23 survivors (p = 0.007). Multivariate Cox regression analysis showed leptin (>13.79 ng/mL) was an independent predictor of survival (p = 0.004). Conclusions. Leptin could be a promising plasma biomarker of AE-IPF occurrence and predictor of survival in IPF patients.
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影响因子：
3.1
作者：
Kythreotis P;Kokkini A;Avgeropoulou S;Hadjioannou A;Anastasakou E;Rasidakis A;Bakakos P
通讯作者：
Bakakos P
影响因子：
2.4
作者：
Manolakopoulos S;Bethanis S;Liapi C;Stripeli F;Sklavos P;Margeli A;Christidou A;Katsanika A;Vogiatzakis E;Tzourmakliotis D;Theocharis S
通讯作者：
Theocharis S
DOI：
10.1007/s13665-013-0065-x
发表时间：
2013-12
期刊：
Current respiratory care reports
影响因子：
--
作者：
Johannson, Kerri;Collard, Harold R
通讯作者：
Collard, Harold R
影响因子：
4.6
作者：
Fernández-Riejos P;Najib S;Santos-Alvarez J;Martín-Romero C;Pérez-Pérez A;González-Yanes C;Sánchez-Margalet V
通讯作者：
Sánchez-Margalet V
影响因子：
64.8
作者：
ZHANG, YY;PROENCA, R;FRIEDMAN, JM
通讯作者：
FRIEDMAN, JM