Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses.
Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses.
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DOI：
10.1084/jem.190.7.895
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发表时间：
1999-10-04
期刊：
影响因子：
--
通讯作者：
Gutierrez-Ramos JC
中科院分区：
文献类型：
--
作者：
Coyle AJ;Lloyd C;Tian J;Nguyen T;Erikkson C;Wang L;Ottoson P;Persson P;Delaney T;Lehar S;Lin S;Poisson L;Meisel C;Kamradt T;Bjerke T;Levinson D;Gutierrez-Ramos JC
T1/ST 2是一种功能未知的孤儿受体，表达于小鼠辅助性T细胞2型（Th 2）的表面，但不表达于Th 1效应细胞。用免疫球蛋白（IG）融合蛋白体外阻断T1/ST 2信号传导抑制Th 2的分化和活化，但不抑制Th 1效应群体。在新生Th 2为主的反应，抗T1/ST 2单克隆抗体（mAb）抑制嗜酸性粒细胞浸润，白细胞介素5的分泌，和IgE的生产。为了确定这些作用是否是通过对Th 2细胞的直接作用介导的，我们接下来使用了Th 1和Th 2介导的肺粘膜免疫应答的鼠过继转移模型。施用T1/ST 2 mAb或T1/ST 2-IG可在体内消除Th 2细胞因子的产生并诱导嗜酸性粒细胞性炎症反应，但未能改变Th 1介导的炎症。总而言之，我们的数据证明了T1/ST 2在Th 2介导的炎症反应中的重要作用，并表明T1/ST 2可能被证明是选择性抑制Th 2免疫反应的新靶点。
T1/ST2 is an orphan receptor of unknown function that is expressed on the surface of murine T helper cell type 2 (Th2), but not Th1 effector cells. In vitro blockade of T1/ST2 signaling with an immunoglobulin (Ig) fusion protein suppresses both differentiation to and activation of Th2, but not Th1 effector populations. In a nascent Th2-dominated response, anti-T1/ST2 monoclonal antibody (mAb) inhibited eosinophil infiltration, interleukin 5 secretion, and IgE production. To determine if these effects were mediated by a direct effect on Th2 cells, we next used a murine adoptive transfer model of Th1- and Th2-mediated lung mucosal immune responses. Administration of either T1/ST2 mAb or T1/ST2-Ig abrogated Th2 cytokine production in vivo and the induction of an eosinophilic inflammatory response, but failed to modify Th1-mediated inflammation. Taken together, our data demonstrate an important role of T1/ST2 in Th2-mediated inflammatory responses and suggest that T1/ST2 may prove to be a novel target for the selective suppression of Th2 immune responses.
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DOI：
10.1084/jem.179.1.299
发表时间：
1994-01-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Seder RA;Germain RN;Linsley PS;Paul WE
通讯作者：
Paul WE
影响因子：
64.5
作者：
Zheng, WP;Flavell, RA
通讯作者：
Flavell, RA
DOI：
10.1164/ajrccm.156.3.9606031
发表时间：
1997-09-01
影响因子：
24.7
作者：
Hamelmann, E;Schwarze, J;Gelfand, EW
通讯作者：
Gelfand, EW
影响因子：
15.3
作者：
Bonecchi, R;Bianchi, G;Bordignon, P P;D'Ambrosio, D;Lang, R;Borsatti, A;Sozzani, S;Allavena, P;Gray, P A;Mantovani, A;Sinigaglia, F
通讯作者：
Sinigaglia, F
影响因子：
4.8
作者：
Torigoe, K;Ushio, S;Kurimoto, M
通讯作者：
Kurimoto, M