PRDM1/BLIMP1 is widely distributed to the nascent fetal-placental interface in the mouse gastrula.
PRDM1/BLIMP1 is widely distributed to the nascent fetal-placental interface in the mouse gastrula.
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DOI：
10.1002/dvdy.24461
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Downs KM
中科院分区：
文献类型：
--
作者：
Mikedis MM;Downs KM
PRDM 1是一种转录抑制因子，有助于原始生殖细胞（PGC）的发育。在早期原肠胚形成期间，外胚层衍生的PRDM 1被认为限于尿囊中的谱系分离的生殖系。然而，鉴于最近的发现，PGCs重叠的尿囊祖细胞池，广泛地有助于胎儿-脐界面，后PRDM 1也可能有助于索马。在小鼠后原肠胚（早期条纹-12-s期，~E6.75-9.0）内，PRDM 1定位于含有推定PGCs的所有组织;然而，PRDM 1也发现于所有三个初级胚层、其衍生物和两个推定的生长中心，尿囊核心区和外胚层嵴。虽然PRDM 1和STELLA共定位主要在后肠内，其中假定的PGC驻留，其他共定位细胞被发现在非PGC网站。另外的PRDM 1和STELLA细胞被发现在整个后部区域，包括后肠，彼此独立。Prdm 1-Cre驱动的报告支持PRDM 1定位在大多数网站，但是，一些Prdm 1后代被发现在网站独立的PRDM 1蛋白，包括尿囊中皮和后肠内胚层。后部PRDM 1比以前认识到的更广泛地促进了胎儿-母体连接的发展，PRDM 1和STELLA在假定的PGC中重叠的同时，也在其他几种组织中共定位。
PRDM1 is a transcriptional repressor that contributes to primordial germ cell (PGC) development. During early gastrulation, epiblast-derived PRDM1 is thought to be restricted to a lineage-segregated germ line in the allantois. However, given recent findings that PGCs overlap an allantoic progenitor pool that contributes widely to the fetal-umbilical interface, posterior PRDM1 may also contribute to soma. Within the posterior mouse gastrula (Early Streak – 12-s stages, ~E6.75–9.0), PRDM1 localized to all tissues containing putative PGCs; however, PRDM1 was also found in all three primary germ layers, their derivatives, and two presumptive growth centers, the Allantoic Core Domain and Ventral Ectodermal Ridge. While PRDM1 and STELLA colocalized predominantly within the hindgut, where putative PGCs reside, other colocalizing cells were found in non-PGC sites. Additional PRDM1 and STELLA cells were found independent of each other throughout the posterior region, including the hindgut. The Prdm1-Cre-driven reporter supported PRDM1 localization in the majority of sites; however, some Prdm1 descendants were found in sites independent of PRDM1 protein, including allantoic mesothelium and hindgut endoderm. Posterior PRDM1 contributes more broadly to the developing fetal-maternal connection than previously recognized, and PRDM1 and STELLA, while overlapping in putative PGCs, also co-localize in several other tissues.
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影响因子：
64.8
作者：
Chen, Michael J.;Yokomizo, Tomomasa;Zeigler, Brandon M.;Dzierzak, Elaine;Speck, Nancy A.
通讯作者：
Speck, Nancy A.
影响因子：
21.3
作者：
Ancelin, Katia;Lange, Ulrike C.;Surani, M. Azim
通讯作者：
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影响因子：
23.9
作者：
Bao, Siqin;Leitch, Harry G.;Gillich, Astrid;Nichols, Jennifer;Tang, Fuchou;Kim, Shinseog;Lee, Caroline;Zwaka, Thomas;Li, Xihe;Surani, M. Azim
通讯作者：
Surani, M. Azim
影响因子：
1.7
作者：
Bowles, J;Teasdale, RP;Koopman, P
通讯作者：
Koopman, P
影响因子：
64.8
作者：
GRUNEBERG, H
通讯作者：
GRUNEBERG, H