Anatomy of the fungal microtubule organizing center, the spindle pole body.

Anatomy of the fungal microtubule organizing center, the spindle pole body.
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真菌微管组织中心的解剖结构,主轴杆体。

DOI:
10.1016/j.sbi.2020.09.008
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发表时间:
2021-03
影响因子:
6.8
通讯作者:
Jaspersen SL
Jaspersen SL
中科院分区:
生物学2区
文献类型:
--
作者:
Jaspersen SL

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真菌界庞大而多样,体现了生态学、生命周期和形态学的极端情况。在细胞层面,真菌之间的多样性在纺锤体极体(SPB)上尤为明显。这种嵌入核膜的结构对微管成核至关重要,在不同真菌之间呈现出截然不同的形态。然而,尽管存在表型多样性,许多纺锤体极体成分是保守的,这表明在结构、功能和复制方面存在共性。在此,我综述了研究最为深入的纺锤体极体的组织形式,并描述了基因组学、遗传学和细胞生物学的进展如何加速了对其他真菌中纺锤体极体结构的了解,从而为微管成核以及其他在真核生物中保守的过程提供了见解。
The fungal kingdom is large and diverse, representing extremes of ecology, life cycles and morphology. At a cellular level, the diversity among fungi is particularly apparent at the spindle pole body (SPB). This nuclear envelope embedded structure, which is essential for microtubule nucleation, shows dramatically different morphologies between different fungi. However, despite phenotypic diversity, many SPB components are conserved, suggesting commonalities in structure, function and duplication. Here, I review the organization of the most well-studied SPBs and describe how advances in genomics, genetics and cell biology have accelerated knowledge of SPB architecture in other fungi, providing insights into microtubule nucleation and other processes conserved across eukaryotes.
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