Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease.
Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease.
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炎症性肠病的肠道自噬及其药理控制
DOI：
10.3389/fimmu.2016.00695
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发表时间：
2016
影响因子：
7.3
通讯作者：
Liu C
中科院分区：
文献类型：
--
作者：
Ke P;Shao BZ;Xu ZQ;Chen XW;Liu C
肠粘膜屏障主要由肠粘液层和上皮细胞组成，在营养吸收和保护免受病原微生物侵害方面起着关键作用。炎症性肠病（inflammatory bowel disease，IBD）主要包括克罗恩病（Crohn's disease）和溃疡性结肠炎（ulcerative colitis，UC），肠黏膜屏障的破坏或肠道内微生物平衡的紊乱是IBD发病和进展的重要原因。自噬是一种进化上保守的分解代谢过程，涉及蛋白质聚集体的降解和受损细胞器的再循环。自噬在炎症性肠病的发病机制和进展中的作用已越来越多地被研究。本文主要介绍潘氏细胞、巨噬细胞和杯状细胞的自噬在炎症性肠病中的作用，以及利用自噬治疗炎症性肠病的几种可能策略。
Intestinal mucosal barrier, mainly composed of the intestinal mucus layer and the epithelium, plays a critical role in nutrient absorption as well as protection from pathogenic microorganisms. It is widely acknowledged that the damage of intestinal mucosal barrier or the disturbance of microorganism balance in the intestinal tract contributes greatly to the pathogenesis and progression of inflammatory bowel disease (IBD), which mainly includes Crohn’s disease and ulcerative colitis. Autophagy is an evolutionarily conserved catabolic process that involves degradation of protein aggregates and damaged organelles for recycling. The roles of autophagy in the pathogenesis and progression of IBD have been increasingly studied. This present review mainly describes the roles of autophagy of Paneth cells, macrophages, and goblet cells in IBD, and finally, several potential therapeutic strategies for IBD taking advantage of autophagy.
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影响因子：
3.1
作者：
Chen, Zhihong;Li, Yanchun;Zhang, Chi;Yi, Hongmei;Wu, Chang;Wang, Junpu;Liu, Yuwu;Tan, Jieqiong;Wen, Jifang
通讯作者：
Wen, Jifang
影响因子：
--
作者：
CHENG, H
通讯作者：
CHENG, H
影响因子：
13.3
作者：
Cabrera, Sandra;Fernandez, Alvaro F.;Lopez-Otin, Carlos
通讯作者：
Lopez-Otin, Carlos
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
4.9
作者：
Ananthakrishnan, Ashwin N.;McGinley, Emily L.;Saeian, Kia
通讯作者：
Saeian, Kia