Effect of light on blinking in patients with idiopathic isolated blepharospasm.
Effect of light on blinking in patients with idiopathic isolated blepharospasm.
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光对特发性孤立性眼睑痉挛患者眨眼的影响
DOI：
10.1016/j.parkreldis.2019.09.010
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发表时间：
2019-10
影响因子：
4.1
通讯作者：
Hallett M
中科院分区：
文献类型：
--
作者：
Wu Y;Cho HJ;Panyakaew P;Savant CS;Wu T;Dang N;Hallett M
黑视素可能参与特发性孤立性眼睑痉挛患者的恐惧症的病理生理过程。我们评估了阻断黑视素吸收波长以减少眼睑痉挛患者眨眼的有效性，作为眼恐怖症的可能替代物。21名参与者（11名眼睑痉挛和10名健康对照）进行了研究。共举行了三次会议：（1）在无干预的情况下测量眨眼率（BR）的基线条件;（2）参与者在不佩戴研究镜片的情况下接受高强度或低强度间歇性光刺激的两种条件;（3）参与者在佩戴四种不同镜片之一时接受高强度间歇性光刺激的四种条件：带有中性灰色或FL-41的有色镜片，或阻挡480 nm或590 nm波长的镀膜镜片。主要结局指标为BR。在昏暗的房间条件下，眼睑痉挛组比对照组眨眼更频繁。患者报告更大的光敏性相比，对照组的调查问卷的基础上，表现出较高的BR与间歇性光刺激。当使用480 nm和590 nm阻断镜片时，两组的BR均降低。在患者中，480-nm和590-nm阻断镜片分别使平均BR减少9.6次眨眼/min和10.3次眨眼/min，而在对照组中，平均BR分别减少4.4次眨眼/min和4.3次眨眼/min。眼睑痉挛患者在光刺激下BR增加，而在590 nm和480 nm阻断镜片下BR降低。480-nm和590-nm涂层镜片可能具有治疗恐惧症的治疗潜力，尽管BR似乎不是恐惧症的最佳生物标志物。
Melanopsin may be involved in the pathophysiology of photophobia in idiopathic isolated blepharospasm. We assessed the efficacy of blocking wavelengths of melanopsin absorption to reduce blinking in blepharospasm as a possible surrogate for photophobia. Twenty-one participants (11 blepharospasm and 10 healthy controls) were studied. There were three sessions: (1) a baseline condition to measure the blink rate (BR) without intervention; (2) two conditions where the participants received intermittent light stimuli with high or low intensity without wearing study lenses; (3) four conditions in which the participants received intermittent light stimuli with high intensity while wearing one of four different lenses: tinted lenses with neutral gray or FL-41, or coated lenses that block 480-nm or 590-nm wavelength. The primary outcome measure was the BR. The blepharospasm group blinked more frequently than controls in dim room conditions. Patients reported greater photosensitivity compared to controls based on the questionnaire and exhibited a higher BR with intermittent light stimuli. The BR decreased for both groups when using 480-nm and 590-nm blocking lenses. In the patients, 480-nm and 590-nm blocking lenses reduced the mean BR by 9.6 blink/min and 10.3 blink/min, respectively, while in the control group, the mean BR decreased by 4.4 blink/min and 4.3 blink/min, respectively. Blepharospasm patients had increased BR with light stimuli which decreased with 590-nm and 480-nm blocking lenses. The 480-nm- and 590-nm- coated lenses might have therapeutic potential in treating photophobia although BR does not appear to be an optimal biomarker for photophobia.
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影响因子：
8.6
作者：
Albanese, Alberto;Bhatia, Kailash;Bressman, Susan B.;DeLong, Mahlon R.;Fahn, Stanley;Fung, Victor S. C.;Hallett, Mark;Jankovic, Joseph;Jinnah, Hyder A.;Klein, Christine;Lang, Anthony E.;Mink, Jonathan W.;Teller, Jan K.
通讯作者：
Teller, Jan K.
DOI：
10.1073/pnas.1008533107
发表时间：
2010-10-05
影响因子：
11.1
作者：
Johnson, Juliette;Wu, Vincent;Copenhagen, David R.
通讯作者：
Copenhagen, David R.
影响因子：
3.4
作者：
Matynia, Anna;Parikh, Sachin;Gorin, Michael B.
通讯作者：
Gorin, Michael B.
DOI：
10.1177/0333102411409076
发表时间：
2011-06
期刊：
Cephalalgia : an international journal of headache
影响因子：
--
作者：
Huang J;Zong X;Wilkins A;Jenkins B;Bozoki A;Cao Y
通讯作者：
Cao Y
影响因子：
64.8
作者：
Dacey, DM;Liao, HW;Gamlin, PD
通讯作者：
Gamlin, PD