Molecular mechanisms of synaptic specificity in developing neural circuits.
Molecular mechanisms of synaptic specificity in developing neural circuits.
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DOI：
10.1016/j.neuron.2010.09.007
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发表时间：
2010-10-06
期刊：
影响因子：
16.2
通讯作者：
Ghosh, Anirvan
中科院分区：
文献类型：
--
作者：
Williams, Megan E.;de Wit, Joris;Ghosh, Anirvan
The function of the brain depends on highly specific patterns of connections between populations of neurons. The establishment of these connections requires the targeting of axons and dendrites to defined zones or laminae, the recognition of individual target cells, the formation of synapses on particular regions of the dendritic tree, and the differentiation of pre- and postsynaptic specializations. Recent studies provide compelling evidence that transmembrane adhesion proteins of the immunoglobulin, cadherin, and leucine-rich repeat protein families, as well as secreted proteins such as semaphorins and FGFs, regulate distinct aspects of neuronal connectivity. These observations suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of synaptic connections in the developing brain.
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DOI：
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发表时间：
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