Impulsive prepotent actions and tics in Tourette disorder underpinned by a common neural network.
Impulsive prepotent actions and tics in Tourette disorder underpinned by a common neural network.
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DOI：
10.1038/s41380-020-00890-5
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发表时间：
2021-07
影响因子：
11
通讯作者：
Worbe Y
中科院分区：
文献类型：
--
作者：
Atkinson-Clement C;Porte CA;de Liege A;Klein Y;Delorme C;Beranger B;Valabregue R;Gallea C;Robbins TW;Hartmann A;Worbe Y
抽动秽语障碍（TD），其特征在于运动和发声抽搐，一般不被认为是冲动的产物，尽管经常与注意缺陷多动障碍和冲动控制障碍。目前尚不清楚哪种类型的冲动，如果有的话，是内在相关的TD，特别是抽搐的严重程度。等待型运动冲动被定义为难以抑制特定动作，与抽搐有一些共同的特征。在一个大组的成年TD患者与健康对照组相比，我们评估了等待运动冲动使用的行为任务，以及结构和功能的基础上的等待冲动和抽搐使用多模态神经成像协议。我们发现，与对照组相比，未用药的TD患者表现出增加的等待冲动，这与共病条件无关，但与抽搐的严重程度相关。抽搐的严重程度并没有直接解释等待冲动，但这种影响是由右侧眶额皮质与双侧尾状核之间的连接介导的。未用药的TD患者的等待冲动也与深层边缘结构中更高的灰质信号相关，以及与皮质和小脑区域在功能水平上的连接。无论是行为表现，也没有结构或功能的相关性与冲动或冲动行为的心理测量一般。总的来说，结果表明，等待冲动TD抽搐的严重程度，眶额皮质与尾状核的功能连接和边缘系统区域内的结构变化。
Tourette disorder (TD), which is characterized by motor and vocal tics, is not in general considered as a product of impulsivity, despite a frequent association with attention deficit hyperactivity disorder and impulse control disorders. It is unclear which type of impulsivity, if any, is intrinsically related to TD and specifically to the severity of tics. The waiting type of motor impulsivity, defined as the difficulty to withhold a specific action, shares some common features with tics. In a large group of adult TD patients compared to healthy controls, we assessed waiting motor impulsivity using a behavioral task, as well as structural and functional underpinnings of waiting impulsivity and tics using multi-modal neuroimaging protocol. We found that unmedicated TD patients showed increased waiting impulsivity compared to controls, which was independent of comorbid conditions, but correlated with the severity of tics. Tic severity did not account directly for waiting impulsivity, but this effect was mediated by connectivity between the right orbito-frontal cortex with caudate nucleus bilaterally. Waiting impulsivity in unmedicated patients with TD also correlated with a higher gray matter signal in deep limbic structures, as well as connectivity with cortical and with cerebellar regions on a functional level. Neither behavioral performance nor structural or functional correlates were related to a psychometric measure of impulsivity or impulsive behaviors in general. Overall, the results suggest that waiting impulsivity in TD was related to tic severity, to functional connectivity of orbito-frontal cortex with caudate nucleus and to structural changes within limbic areas.
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影响因子：
11
作者：
Greene DJ;Williams Iii AC;Koller JM;Schlaggar BL;Black KJ;The Tourette Association of America Neuroimaging Consortium
通讯作者：
The Tourette Association of America Neuroimaging Consortium
影响因子：
5
作者：
Korte, S. Mechiel;Prins, Jolanda;Guentuerkuen, Onur
通讯作者：
Guentuerkuen, Onur
影响因子：
3.4
作者：
Baunez, C;Robbins, TW
通讯作者：
Robbins, TW
影响因子：
3.4
作者：
Agnoli, Laura;Carli, Mirjana
通讯作者：
Carli, Mirjana
影响因子：
2.6
作者：
Maigaard, Katrine;Nejad, Ayna Baladi;Plessen, Kerstin Jessica
通讯作者：
Plessen, Kerstin Jessica