The functional diversity of Aurora kinases: a comprehensive review.
The functional diversity of Aurora kinases: a comprehensive review.
复制标题
DOI：
10.1186/s13008-018-0040-6
复制
发表时间：
2018
期刊：
影响因子：
2.3
通讯作者：
Rogister B
中科院分区：
文献类型：
--
作者：
Willems E;Dedobbeleer M;Digregorio M;Lombard A;Lumapat PN;Rogister B
极光激酶是丝氨酸/苏氨酸激酶，对有丝分裂的发生和进展至关重要。Aurora成员具有相似的蛋白质结构和激酶活性，但表现出不同的细胞和亚细胞定位。AurA通过促进中心体成熟和有丝分裂纺锤体组装来促进G2/M转变。AurB和AurC是染色体-乘客复合物蛋白，对染色体与着丝点结合和染色体分离至关重要。AurB的细胞分布普遍，而AurC的表达主要局限于具有减数分裂活性的生殖细胞。在人类肿瘤中，所有Aurora激酶成员都发挥与其有丝分裂活性相关的致瘤作用，并促进癌细胞的存活和增殖。此外，AurA还具有与有丝分裂无关的肿瘤促进作用，包括肿瘤干性、上皮细胞向间质细胞的转化和侵袭。在这篇综述中，我们的目的是了解极光激酶在各种类型的人类细胞，包括肿瘤细胞中的功能相互作用。了解极光激酶的功能多样性有助于评估它们作为癌症潜在治疗靶点的相关性。
Aurora kinases are serine/threonine kinases essential for the onset and progression of mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit distinct cellular and subcellular localization. AurA favors the G2/M transition by promoting centrosome maturation and mitotic spindle assembly. AurB and AurC are chromosome-passenger complex proteins, crucial for chromosome binding to kinetochores and segregation of chromosomes. Cellular distribution of AurB is ubiquitous, while AurC expression is mainly restricted to meiotically-active germ cells. In human tumors, all Aurora kinase members play oncogenic roles related to their mitotic activity and promote cancer cell survival and proliferation. Furthermore, AurA plays tumor-promoting roles unrelated to mitosis, including tumor stemness, epithelial-to-mesenchymal transition and invasion. In this review, we aim to understand the functional interplay of Aurora kinases in various types of human cells, including tumor cells. The understanding of the functional diversity of Aurora kinases could help to evaluate their relevance as potential therapeutic targets in cancer.
登录
查看更多内容
影响因子：
7.5
作者：
Carmena M;Ruchaud S;Earnshaw WC
通讯作者：
Earnshaw WC
影响因子：
11.4
作者：
Andrésson, T;Ruderman, JV
通讯作者：
Ruderman, JV
影响因子：
5.4
作者：
Bayliss, Richard;Burgess, Selena G.;McIntyre, Patrick J.
通讯作者：
McIntyre, Patrick J.
DOI：
10.1002/cjp2.6
发表时间：
2015-01
期刊：
The journal of pathology. Clinical research
影响因子：
--
作者：
Aradottir M;Reynisdottir ST;Stefansson OA;Jonasson JG;Sverrisdottir A;Tryggvadottir L;Eyfjord JE;Bodvarsdottir SK
通讯作者：
Bodvarsdottir SK
影响因子：
14.9
作者：
Chan FL;Vinod B;Novy K;Schittenhelm RB;Huang C;Udugama M;Nunez-Iglesias J;Lin JI;Hii L;Chan J;Pickett HA;Daly RJ;Wong LH
通讯作者：
Wong LH