Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins.
Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins.
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DOI：
10.1016/j.ceb.2009.09.008
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发表时间：
2009-12
影响因子：
7.5
通讯作者：
Earnshaw WC
中科院分区：
文献类型：
--
作者：
Carmena M;Ruchaud S;Earnshaw WC
保守的Aurora蛋白激酶家族已成为有丝分裂和胞质分裂的重要调节因子。尽管Aurora A和Aurora B高度同源，但它们有非常不同的定位和功能：Aurora A与纺锤体极结合，调节进入有丝分裂、中心体成熟和纺锤体组装；Aurora B是染色体乘客复合体(CPC)的成员，它从有丝分裂早期的内着丝粒转移到纺锤体中部、赤道皮质和晚期有丝分裂和胞质分裂的中体。极光B的功能包括调节染色体-微管相互作用、凝聚力、纺锤体稳定性和胞质分裂。这篇综述将集中于相互作用的蛋白质如何通过靶向不同的亚细胞位置和调节它们的活性来实现这种功能多样性。
The conserved Aurora family of protein kinases have emerged as crucial regulators of mitosis and cytokinesis. Despite their high degree of homology, Aurora A and B have very distinctive localisations and functions: Aurora A associates with the spindle poles to regulate entry into mitosis, centrosome maturation and spindle assembly; Aurora B is a member of the Chromosomal Passenger Complex (CPC) that transfers from the inner centromere in early mitosis to the spindle midzone, equatorial cortex and midbody in late mitosis and cytokinesis. Aurora B functions include regulation of chromosome–microtubule interactions, cohesion, spindle stability and cytokinesis. This review will focus on how interacting proteins make this functional diversity possible by targeting the kinases to different subcellular locations and regulating their activity.
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DOI：
10.1083/jcb.105.5.2053
发表时间：
1987-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cooke CA;Heck MM;Earnshaw WC
通讯作者：
Earnshaw WC
影响因子：
21.3
作者：
Bakhoum, Samuel F.;Thompson, Sarah L.;Manning, Amity L.;Compton, Duane A.
通讯作者：
Compton, Duane A.
DOI：
10.1083/jcb.153.4.865
发表时间：
2001-05-14
期刊：
The Journal of cell biology
影响因子：
--
作者：
Adams RR;Maiato H;Earnshaw WC;Carmena M
通讯作者：
Carmena M
影响因子：
11.8
作者：
Dai, Jun;Sullivan, Beth A.;Higgins, Jonathan M. G.
通讯作者：
Higgins, Jonathan M. G.
影响因子：
10.5
作者：
Biggins, S;Murray, AW
通讯作者：
Murray, AW