Diversity of immune cell types in multiple sclerosis and its animal model: Pathological and therapeutic implications.
Diversity of immune cell types in multiple sclerosis and its animal model: Pathological and therapeutic implications.
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多发性硬化症免疫细胞类型的多样性及其动物模型：病理和治疗意义。
DOI：
10.1002/jnr.24023
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发表时间：
2017-10
影响因子：
4.2
通讯作者：
Jin T
中科院分区：
文献类型：
--
作者：
Cheng Y;Sun L;Xie Z;Fan X;Cao Q;Han J;Zhu J;Jin T
多发性硬化症（MS）是一种中枢神经系统的炎症性脱髓鞘疾病，其自身免疫攻击髓鞘和轴突的组成部分。该疾病的病因在很大程度上仍然未知，但人们普遍认为，MS的发展可能是环境因素与遗传易感性相互作用的结果。目前的治疗方法只能改善ms的临床症状或减少复发的频率，大多数用于该疾病的药物广泛抑制免疫效应细胞的功能，这可能导致严重的副作用。因此，需要新的治疗方法来提高疗效和降低毒性。为此，基于细胞的治疗方法在多发性硬化症的治疗中越来越受到关注。几种免疫调节细胞类型，包括调节性T细胞、调节性B细胞、M2巨噬细胞、耐受性树突状细胞和干细胞，已被开发为治疗多发性硬化症的新治疗工具。本文综述了这些细胞群在治疗多发性硬化症及其动物模型、实验性自身免疫性脑脊髓炎、并呼吁进一步研究这些细胞在多发性硬化治疗中的应用和机制©2017 Wiley期刊出版的《作者神经科学研究杂志》。
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system with an autoimmune attack on the components of the myelin sheath and axons. The etiology of the disease remains largely unknown, but it is commonly acknowledged that the development of MS probably results from the interaction of environmental factors in conjunction with a genetic predisposition. Current therapeutic approaches can only ameliorate the clinical symptoms or reduce the frequency of relapse in MS. Most drugs used in this disease broadly suppress the functions of immune effector cells, which can result in serious side effects. Thus, new therapeutic methods resulting in greater efficacy and lower toxicity are needed. Toward this end, cell‐based therapies are of increasing interest in the treatment of MS. Several immunoregulatory cell types, including regulatory T cells, regulatory B cells, M2 macrophages, tolerogenic dendritic cells, and stem cells, have been developed as novel therapeutic tools for the treatment of MS. In this Review, we summarize studies on the application of these cell populations for the treatment of MS and its animal model, experimental autoimmune encephalomyelitis, and call for further research on applications and mechanisms by which these cells act in the treatment of MS. © 2017 The Authors Journal of Neuroscience Research Published by Wiley Periodicals, Inc.
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影响因子：
48
作者：
Connick, Peter;Kolappan, Madhan;Crawley, Charles;Webber, Daniel J.;Patani, Rickie;Michell, Andrew W.;Du, Ming-Qing;Luan, Shi-Lu;Altmann, Daniel R.;Thompson, Alan J.;Compston, Alastair;Scott, Michael A.;Miller, David H.;Chandran, Siddharthan
通讯作者：
Chandran, Siddharthan
影响因子：
9.1
作者：
Costantino, Cristina Maria;Baecher-Allan, Clare;Hafler, David A.
通讯作者：
Hafler, David A.
影响因子：
2.5
作者：
Duffy SS;Lees JG;Moalem-Taylor G
通讯作者：
Moalem-Taylor G
影响因子：
7.3
作者：
Bakdash G;Sittig SP;van Dijk T;Figdor CG;de Vries IJ
通讯作者：
de Vries IJ
影响因子：
4.6
作者：
Buc M
通讯作者：
Buc M