Multiple sclerosis and regulatory T cells.
Multiple sclerosis and regulatory T cells.
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DOI：
10.1007/s10875-008-9236-x
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发表时间：
2008-11
影响因子：
9.1
通讯作者：
Hafler, David A.
中科院分区：
文献类型：
--
作者：
Costantino, Cristina Maria;Baecher-Allan, Clare;Hafler, David A.
多发性硬化症（MS）是一种复杂的遗传性疾病，其特征是中枢神经系统（CNS）的慢性炎症。MS的病理学主要归因于穿透血脑屏障并在CNS内被激活的自身反应性效应T细胞。由于自身反应性T细胞存在于MS患者和健康个体的血液中，因此存在其他调节机制以防止自身反应性T细胞引起免疫紊乱。调节性T（Treg）细胞的主动抑制在体内自身抗原反应性T细胞的控制和外周耐受的诱导中起关键作用。特别地，抗原特异性Treg细胞在赋予对器官特异性自身免疫的遗传抗性和限制自身免疫组织损伤中的重要性已经在包括MS的许多疾病模型中被记录。我们已经发现MS患者中的Treg频率与对照相比没有变化，但是它们在体外测量的功能可能减弱，这与体内抑制活性受损相关。这篇综述讨论了MS的免疫病理学，特别关注调节性T细胞及其开发治疗这种疾病的新疗法的潜力。
Multiple sclerosis (MS) is a complex genetic disease characterized by chronic inflammation of the central nervous system (CNS). The pathology of MS is largely attributed to autoreactive effector T cells that penetrate the blood-brain barrier and become activated within the CNS. As autoreactive T cells are present in the blood of both patients with MS and healthy individuals, other regulatory mechanisms exist to prevent autoreactive T cells from causing immune disorders. Active suppression by regulatory T (Treg) cells plays a key role in the control of self-antigen-reactive T cells and the induction of peripheral tolerance in vivo. In particular, the importance of antigen-specific Treg cells in conferring genetic resistance to organ specific autoimmunity and in limiting autoimmune tissue damage has been documented in many disease models including MS. We have found that the frequency of Tregs in MS patients is unchanged from controls, but their function measured in vitro may be diminished, correlating with impaired inhibitory activity in vivo. This review discusses the immunopathology of MS with particular focus given to regulatory T cells and their potential for the development of new therapies to treat this disease.
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DOI：
10.1084/jem.193.11.1303
发表时间：
2001-06-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dieckmann D;Plottner H;Berchtold S;Berger T;Schuler G
通讯作者：
Schuler G
影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
影响因子：
4.4
作者：
Baecher-Allan, Clare;Wolf, Elizabeth;Haller, David A.
通讯作者：
Haller, David A.
影响因子：
3.3
作者：
Gärtner, D;Hoff, H;Brunner-Weinzierl, MC
通讯作者：
Brunner-Weinzierl, MC
影响因子：
11.2
作者：
HAUSER, SL;BHAN, AK;WEINER, HL
通讯作者：
WEINER, HL