Evaluating the contribution of gut microbiome to the variance of porcine serum glucose and lipid concentration.
Evaluating the contribution of gut microbiome to the variance of porcine serum glucose and lipid concentration.
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评估肠道微生物组对猪血清葡萄糖和脂质浓度变化的贡献
DOI：
10.1038/s41598-017-15044-x
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发表时间：
2017-11-02
影响因子：
4.6
通讯作者：
Huang L
中科院分区：
文献类型：
--
作者：
Huang X;Fang S;Yang H;Gao J;He M;Ke S;Zhao Y;Chen C;Huang L
血清葡萄糖和血脂是宿主代谢状况的重要指标。宿主和肠道微生物的相互作用调节新陈代谢过程。然而，肠道微生物组对血清葡萄糖和血脂的变化有多大影响尚不清楚。在此，我们对 240 头中国二花莲猪进行了基于 16S rRNA 基因的盲肠微生物组与血清葡萄糖和脂质浓度之间的关联研究。我们鉴定了数十种与血清葡萄糖和脂质相关的细菌类群。产生丁酸的细菌与血糖水平显着相关。变形菌门和梭杆菌门的病原菌与血脂水平升高显着相关，而乳酸杆菌和芽孢杆菌与血脂水平呈负相关。交叉验证分析显示，肠道微生物组解释了23.8%的血糖变异和1.6%~6.0%的血脂变异。此外，与营养摄入、运输和碳水化合物代谢相关的预测功能能力与血糖水平显着相关，而与抗氧化代谢和胆汁合成相关的途径往往与血脂水平相关。这些结果为深入了解肠道微生物组对猪血清葡萄糖和脂质水平的影响提供了有意义的信息。
Serum glucose and lipids are important indicators for host metabolic condition. Interaction of host and gut microbes regulates the metabolism process. However, how much the gut microbiome contributes to the variance of serum glucose and lipids is largely unknown. Here we carried out a 16S rRNA gene based association study between cecum microbiome and the concentration of serum glucose and lipids in 240 Chinese Erhualian pigs. We identified tens of bacterial taxa associated with serum glucose and lipids. The butyrate-producing bacteria were significantly associated with serum glucose level. The pathogenic bacteria belonging to Proteobacteria and Fusobacteria showed significant associations with increased serum lipid levels, while the bacteria Lactobacillus and Bacilli had negative correlations with serum lipids. Cross-validation analysis revealed that 23.8% variation of serum glucose and 1.6%~6.0% variations of serum lipids were explained by gut microbiome. Furthermore, predicted function capacities related to nutrition intake, transport and carbohydrate metabolism were significantly associated with serum glucose level, while the pathways related to antioxidant metabolism and bile synthesis tended to be associated with serum lipid level. The results provide meaningful information to get insight into the effect of gut microbiome on serum glucose and lipid levels in pigs.
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影响因子：
3.7
作者：
Lecomte V;Kaakoush NO;Maloney CA;Raipuria M;Huinao KD;Mitchell HM;Morris MJ
通讯作者：
Morris MJ
DOI：
10.1016/0010-406x(70)90488-3
发表时间：
1970-01-01
期刊：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY
影响因子：
--
作者：
ANAND, RS;BLACK, AL
通讯作者：
BLACK, AL
影响因子：
11
作者：
Looft, Torey;Allen, Heather K.;Stanton, Thaddeus B.
通讯作者：
Stanton, Thaddeus B.
DOI：
10.1007/978-1-4939-6685-1_9
发表时间：
2017-01-01
期刊：
ORAL BIOLOGY: MOLECULAR TECHNIQUES AND APPLICATIONS, 2ND EDITION
影响因子：
--
作者：
Lawley, Blair;Tannock, Gerald W.
通讯作者：
Tannock, Gerald W.
影响因子：
3.9
作者：
MATTAELAMMOURI, G;JANATIIDRISSI, R;GAY, R
通讯作者：
GAY, R