Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice.
Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice.
复制标题
DOI：
10.1016/j.fct.2016.12.004
复制
发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Klaassen CD
中科院分区：
文献类型：
--
作者：
Rockwell CE;Turley AE;Cheng X;Fields PE;Klaassen CD
全氟农酸(PFNA)是一种结构上与全氟辛酸(PFOA)和全氟辛烷磺酸(PFOS)相关的全氟烷基物质(PFAS)。虽然全氟辛烷磺酸和全氟辛烷磺酸是已知的免疫毒物，但全氟辛烷磺酸的特性较差。我们先前的研究表明，PFNA对白细胞数量和免疫功能具有免疫调节作用。目前的研究试图确定在接触PFNA 28天后，免疫系统是否恢复，以及恢复到什么程度。所有测量的参数均未完全恢复。一些参数已部分恢复，包括脾大小减小和胸腺中CD4+/CD8+双阳性细胞比例降低。暴露28d后，PFNA的大部分效应没有变化，包括完整胸腺细胞比例下降(由FSC和SSC确定)，脾中免疫细胞比例和胸腺中CD4+、CD8+和双阴性细胞比例的变化。值得注意的是，在活体内，PFNA显著增加了对脂多糖的肿瘤坏死因子α反应，并且在暴露后28天没有明显的恢复。PFNA对CD_4~+T细胞、CD_8~+T细胞和CD_(19)~+细胞的影响在女性更为明显。目前的研究表明，单次高剂量接触PFNA(例如，在职业环境中可能意外发生)对免疫系统有长期影响。
Perfluorononanoic acid (PFNA) is a perfluoroalkyl substance (PFAS) that is structurally related to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). Whereas PFOA and PFOS are known immunotoxicants, PFNA is less well characterized. Our previous study showed that PFNA has immunomodulatory effects on leukocyte populations and immune function. The present studies sought to determine whether, and to what degree, the immune system recovered 28 days after PFNA exposure. None of the parameters measured had fully recovered. A few parameters had partially recovered, including decreased spleen size and the decreased ratio of the CD4+/CD8+ double-positive population in thymus. The majority of effects of PFNA remained unchanged 28 days after exposure, including decreased proportion of intact thymocytes (as determined by FSC vs SSC), alterations in the ratios of immune cell populations in spleen and the CD4+, CD8+ and double-negative populations in thymus. Notably, PFNA markedly increased the TNFα response to LPS in vivo, and no recovery was evident 28 days after exposure. The effect of PFNA on CD4+ T cells, CD8+ T cells and CD19+ cells was more pronounced in females. The current study demonstrates that a single high dose exposure to PFNA (e.g. as might occur accidentally in an occupational setting) has long-lasting effects on the immune system.
登录
查看更多内容
影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
5.8
作者：
Yang, Q;Xie, Y;DePierre, JW
通讯作者：
DePierre, JW
DOI：
10.1097/01.jom.0000233380.13087.37
发表时间：
2006-08-01
影响因子：
3.2
作者：
Emmett, Edward Anthony;Zhang, Hong;Shaw, Leslie Michael
通讯作者：
Shaw, Leslie Michael
影响因子：
4.5
作者：
Dong, Guang-Hui;Zhang, Ying-Hua;He, Qin-Cheng
通讯作者：
He, Qin-Cheng
影响因子：
5.6
作者：
Yang, Q;Abedi-Valugerdi, M;DePierre, JW
通讯作者：
DePierre, JW