Double insult: flu bug enhances SARS-CoV-2 infectivity.

Double insult: flu bug enhances SARS-CoV-2 infectivity.
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DOI:
10.1038/s41422-021-00498-6
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发表时间:
2021-05
期刊:
影响因子:
44.1
通讯作者:
Jiang S
Jiang S
中科院分区:
生物学1区
文献类型:
--
作者:
Su S;Liu Z;Jiang S

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持续的COVID-19大流行和SARS-CoV-2变体的出现可能导致这种疾病像季节性流感一样转变为地方性疾病。在最近的一项研究中,Bai等人报道了甲型流感病毒的预感染增强了SARS-CoV-2的传染性,呼吁开发一种泛流感- covid -19疫苗,以对抗IAV、SARS-CoV-2或它们的合并感染。在进化压力下,由SARS-CoV-2引起的COVID-19大流行可能会变得更加严重,因为出现了具有改变的传播性、发病机制和毒力的变体,或两者结合。此外,COVID-19康复者或疫苗接种者体内的抗体可能会驱使SARS-CoV-2进一步适应并变异为逃逸变体。预计COVID-19可能会像季节性流感和由其他人类冠状病毒(hcov)引起的普通感冒一样转变为地方病。1这是一个值得关注的问题,涉及SARS-CoV-2与其他常见病毒,特别是甲型流感病毒(IAV)共同感染的综合影响,甲型流感病毒引起的呼吸道症状与某些冠状病毒相似。
The continuing COVID-19 pandemic and emergence of SARS-CoV-2 variants may cause this disease to transit into endemicity like seasonal flu. In a recent study, Bai et al. reported that preinfection of influenza A virus enhanced SARS-CoV-2 infectivity, calling for the development of a pan-flu-COVID-19 vaccine to combat infection of IAV, SARS-CoV-2, or their coinfection.The COVID-19 pandemic, caused by SARS-CoV-2, may become even more serious by the emergence of variants with altered transmissibility, pathogenesis, and virulence, or a combination, under evolutionary pressure. In addition, antibodies in COVID-19 convalescents or vaccinees may drive SARS-CoV-2 to further adapt and mutate into escape variants. It is anticipated that COVID-19 may transit into endemicity like seasonal flu and the common cold caused by other human coronaviruses (HCoVs). 1 This is a matter of concern on the combined effect of coinfection between SARS-CoV-2 and other common viruses, especially the influenza A virus (IAV), which causes respiratory symptoms similar to some coronaviruses.
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