Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal.

Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal.
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2型糖尿病和代谢综合征的饮食碳水化合物限制:进行严格评估的时间。

DOI:
10.1186/1743-7075-5-9
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发表时间:
2008-04-08
影响因子:
4.5
通讯作者:
Vernon MC
Vernon MC
中科院分区:
医学3区
文献类型:
--
作者:
Accurso A;Bernstein RK;Dahlqvist A;Draznin B;Feinman RD;Fine EJ;Gleed A;Jacobs DB;Larson G;Lustig RH;Manninen AH;McFarlane SI;Morrison K;Nielsen JV;Ravnskov U;Roth KS;Silvestre R;Sowers JR;Sundberg R;Volek JS;Westman EC;Wood RJ;Wortman J;Vernon MC

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目前治疗代谢综合征和2型糖尿病的营养方法通常依赖于减少饮食中的脂肪。这种方法的成功是有限的,治疗更普遍地依赖于药理学。本文的论点是,重新评估碳水化合物限制的作用,这是解决这个问题的历史和直观的方法,可能提供一种替代的、可能更好的饮食策略。其基本原理是,限制碳水化合物可以改善血糖控制,减少胰岛素波动,这是主要目标。实验总结表明,限制碳水化合物饮食在减肥方面至少与低脂饮食一样有效,用脂肪代替碳水化合物通常有利于降低心血管疾病的风险。限制碳水化合物的这些有益效果并不需要减肥。最后,重申一点,限制碳水化合物可以改善代谢综合征的所有特征。
Current nutritional approaches to metabolic syndrome and type 2 diabetes generally rely on reductions in dietary fat. The success of such approaches has been limited and therapy more generally relies on pharmacology. The argument is made that a re-evaluation of the role of carbohydrate restriction, the historical and intuitive approach to the problem, may provide an alternative and possibly superior dietary strategy. The rationale is that carbohydrate restriction improves glycemic control and reduces insulin fluctuations which are primary targets. Experiments are summarized showing that carbohydrate-restricted diets are at least as effective for weight loss as low-fat diets and that substitution of fat for carbohydrate is generally beneficial for risk of cardiovascular disease. These beneficial effects of carbohydrate restriction do not require weight loss. Finally, the point is reiterated that carbohydrate restriction improves all of the features of metabolic syndrome.
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