Long-term consequences of Sox9 depletion on inner ear development.
Long-term consequences of Sox9 depletion on inner ear development.
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DOI：
10.1002/dvdy.22259
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发表时间：
2010-04
影响因子：
2.5
通讯作者：
Saint-Jeannet, Jean-Pierre
中科院分区：
文献类型：
--
作者：
Park, Byung-Yong;Saint-Jeannet, Jean-Pierre
转录因子Sox9与几个物种的内耳形成有关。为了研究Sox9耗竭对内耳发育的长期影响，我们分析了注射越来越多的Sox9吗啉反义寡核苷酸所产生的Sox9耗竭非洲爪哇蝌蚪的内耳结构。我们发现，Sox9缺失导致了前庭结构、半规管和椭圆形的主要发育缺陷，而腹侧定位的球囊在这些胚胎中受到的影响较小。与这一表型一致，我们观察到Wnt3a在Sox9变异体耳泡中的背部表达特异性丧失，与假定上皮区域的细胞死亡增加和细胞增殖减少有关。我们认为，除了在胎盘规范中的早期作用外，Sox9也是维持耳廓上皮中的祖细胞所必需的。
The transcription factor Sox9 has been implicated in inner ear formation in several species. To investigate the long-term consequences of Sox9 depletion on inner ear development we analyzed the inner ear architecture of Sox9-depleted Xenopus tadpoles generated by injection of increasing amounts of Sox9 morpholino antisense oligonucleotides. We found that Sox9-depletion resulted in major defects in the development of vestibular structures, semicircular canals and utricle, while the ventrally located saccule was less severely affected in these embryos. Consistent with this phenotype we observed a specific loss of the dorsal expression of Wnt3a expression in the otic vesicle of Sox9 morphants, associated with an increase in cell death and a reduction in cell proliferation in the region of the presumptive otic epithelium. We propose that in addition to its early role in placode specification, Sox9 is also required for the maintenance of progenitors in the otic epithelium.
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影响因子：
3.5
作者：
Bernard, P;Tang, PY;Vilain, E
通讯作者：
Vilain, E
DOI：
10.1002/neu.10098
发表时间：
2002-11-05
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Fritzsch, B;Beisel, KW;Reichardt, LF
通讯作者：
Reichardt, LF
DOI：
10.1073/pnas.111092198
发表时间：
2001-06-05
影响因子：
11.1
作者：
Bi, WM;Huang, WD;de Crombrugghe, B
通讯作者：
de Crombrugghe, B
半规管大小决定了爪蟾幼虫角前庭眼反射的发育起始。
DOI：
10.1523/jneurosci.1288-08.2008
发表时间：
2008-08-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lambert FM;Beck JC;Baker R;Straka H
通讯作者：
Straka H
影响因子：
2.7
作者：
Kil, SH;Collazo, A
通讯作者：
Collazo, A