Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy.
Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy.
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禁食周期阻碍肿瘤的生长，并使一系列癌细胞类型对化学疗法敏感。
DOI：
10.1126/scitranslmed.3003293
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发表时间：
2012-03-07
影响因子：
17.1
通讯作者：
Longo VD
中科院分区：
文献类型：
--
作者：
Lee C;Raffaghello L;Brandhorst S;Safdie FM;Bianchi G;Martin-Montalvo A;Pistoia V;Wei M;Hwang S;Merlino A;Emionite L;de Cabo R;Longo VD
短期饥饿（或禁食）可以保护正常细胞，小鼠和潜在的人类免受各种化疗药物的有害副作用。在这里，我们表明，处理与饥饿条件敏感酵母细胞（酿酒酵母）表达癌基因样RAS 2 val 19氧化应激和15的17个哺乳动物癌细胞系化疗药物。饥饿循环在延缓不同肿瘤的进展方面与化疗药物一样有效，并增加了这些药物对黑色素瘤、神经胶质瘤和乳腺癌细胞的有效性。在神经母细胞瘤小鼠模型中，禁食周期加化疗药物（但不是单独治疗）导致长期无癌生存。在4 T1乳腺癌细胞中，短期饥饿导致应激敏感性Akt和S6激酶磷酸化增加，氧化应激增加，caspase-3裂解，DNA损伤和凋亡。这些研究表明，多个周期的禁食促进了各种肿瘤的差异性应激敏感化，并可能取代或增强某些化疗药物治疗各种癌症的疗效。
Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs. Here, we show that treatment with starvation conditions sensitized yeast cells (Saccharomyces cerevisiae) expressing the oncogene-like RAS2val19 to oxidative stress and 15 of 17 mammalian cancer cell lines to chemotherapeutic agents. Cycles of starvation were as effective as chemotherapeutic agents in delaying progression of different tumors and increased the effectiveness of these drugs against melanoma, glioma, and breast cancer cells. In mouse models of neuroblastoma, fasting cycles plus chemotherapy drugs—but not either treatment alone—resulted in long-term cancer-free survival. In 4T1 breast cancer cells, short-term starvation resulted in increased phosphorylation of the stress-sensitizing Akt and S6 kinases, increased oxidative stress, caspase-3 cleavage, DNA damage, and apoptosis. These studies suggest that multiple cycles of fasting promote differential stress sensitization in a wide range of tumors and could potentially replace or augment the efficacy of certain chemotherapy drugs in the treatment of various cancers.
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影响因子：
7.8
作者：
Fontana L;Weiss EP;Villareal DT;Klein S;Holloszy JO
通讯作者：
Holloszy JO
影响因子：
4.5
作者：
Fabrizio P;Hoon S;Shamalnasab M;Galbani A;Wei M;Giaever G;Nislow C;Longo VD
通讯作者：
Longo VD
影响因子：
3
作者：
Kim, SY;Volsky, DJ
通讯作者：
Volsky, DJ
影响因子：
11.2
作者：
Lee C;Safdie FM;Raffaghello L;Wei M;Madia F;Parrella E;Hwang D;Cohen P;Bianchi G;Longo VD
通讯作者：
Longo VD
影响因子：
13.8
作者：
Longo VD;Fontana L
通讯作者：
Fontana L