Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.
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DOI：
10.1111/j.1474-9726.2008.00417.x
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发表时间：
2008-10
期刊：
影响因子：
7.8
通讯作者：
Holloszy JO
中科院分区：
文献类型：
--
作者：
Fontana L;Weiss EP;Villareal DT;Klein S;Holloszy JO
胰岛素/IGF-I信号通路中的功能降低突变增加了许多物种的最大寿命和健康寿命。热量限制（CR）可使血清IGF-1浓度降低约40%，预防癌症并减缓啮齿动物的衰老。然而，CR与充足的营养对人类循环IGF-1水平的长期影响尚不清楚。在这里，我们报告了两项长期CR研究（1年和6年）的数据，表明无营养不良的重度CR不会改变人类IGF-1和IGF-1：IGFBP-3的比例水平。相比之下，总的和游离的IGF-1浓度显着低于中度蛋白质限制的个人。在6名实施CR的志愿者中，将蛋白质摄入量从平均每天1.67 g kg −1体重减少到每天0.95 g kg −1体重，持续3周，导致血清IGF-1从194 ng mL −1减少到152 ng mL −1。这些发现表明，与啮齿类动物不同，长期重度CR不会降低人类的血清IGF-1浓度和IGF-1：IGFBP-3比值。此外，我们的数据提供的证据表明，蛋白质摄入量是人体循环IGF-1水平的关键决定因素，并表明减少蛋白质摄入量可能成为抗癌和抗衰老饮食干预的重要组成部分。
Reduced function mutations in the insulin/IGF-I signaling pathway increase maximal lifespan and health span in many species. Calorie restriction (CR) decreases serum IGF-1 concentration by ~40%, protects against cancer and slows aging in rodents. However, the long-term effects of CR with adequate nutrition on circulating IGF-1 levels in humans are unknown. Here we report data from two long-term CR studies (1 and 6 years) showing that severe CR without malnutrition did not change IGF-1 and IGF-1 : IGFBP-3 ratio levels in humans. In contrast, total and free IGF-1 concentrations were significantly lower in moderately protein-restricted individuals. Reducing protein intake from an average of 1.67 g kg −1 of body weight per day to 0.95 g kg −1 of body weight per day for 3 weeks in six volunteers practicing CR resulted in a reduction in serum IGF-1 from 194 ng mL −1 to 152 ng mL −1 . These findings demonstrate that, unlike in rodents, long-term severe CR does not reduce serum IGF-1 concentration and IGF-1 : IGFBP-3 ratio in humans. In addition, our data provide evidence that protein intake is a key determinant of circulating IGF-1 levels in humans, and suggest that reduced protein intake may become an important component of anticancer and anti-aging dietary interventions.
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DOI：
10.1073/pnas.0308291101
发表时间：
2004-04-27
影响因子：
11.1
作者：
Fontana, L;Meyer, TE;Holloszy, JO
通讯作者：
Holloszy, JO
DOI：
10.1073/pnas.111158898
发表时间：
2001-06-05
影响因子：
11.1
作者：
Flurkey, K;Papaconstantinou, J;Harrison, DE
通讯作者：
Harrison, DE
影响因子：
4.8
作者：
Sanz, Alberto;Caro, Pilar;Barja, Gustavo
通讯作者：
Barja, Gustavo
影响因子：
56.9
作者：
Kurosu, H;Yamamoto, M;Kuro-o, M
通讯作者：
Kuro-o, M
影响因子：
5.8
作者：
Fontana, Luigi;Klein, Samuel;Premachandra, Bhartur N.
通讯作者：
Premachandra, Bhartur N.