Psychiatric implications of basic and clinical studies with corticotropin-releasing factor.

Psychiatric implications of basic and clinical studies with corticotropin-releasing factor.
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促肾上腺皮质激素释放因子的基础和临床研究的精神病学意义。

DOI:
10.1176/ajp.141.5.619
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发表时间:
1984
期刊:
The American journal of psychiatry
影响因子:
--
通讯作者:
D. Loriaux
D. Loriaux
中科院分区:
--
文献类型:
--
作者:
P. Gold;G. Chrousos;C. Kellner;R. Post;A. Roy;P. Augerinos;Heinrich M. Schulte;E. Oldfield;D. Loriaux

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促肾上腺皮质激素释放因子(CRF)是一种新发现的神经肽,被认为是促垂体促肾上腺皮质激素(ACTH)分泌的主要刺激因子。从实验室动物和灵长类动物获得的证据表明,CRF不仅刺激垂体-肾上腺轴,但也影响了几个方面的中枢神经系统功能,这可能是相关的精神疾病。在临床上,管理绵羊CRF超过150个人的经验表明,CRF可以帮助解决鉴别诊断的困境,在患者的各种疾病的下丘脑-垂体-肾上腺轴,并在进一步了解的病理生理条件,如库欣病和抑郁症。
Corticotropin-releasing factor (CRF) is a newly sequenced neuropeptide thought to be a principal stimulus to pituitary corticotropin (ACTH) secretion. Evidence obtained from laboratory animals and primates is reviewed which indicates that CRF not only stimulates the pituitary-adrenal axis but also influences several aspects of CNS function which may be of relevance to psychiatric illness. Clinically, experience in administering ovine CRF to more than 150 individuals shows that CRF can be helpful in resolving differential diagnostic dilemmas in patients with various disorders of the hypothalamic-pituitary-adrenal axis and in furthering an understanding of the pathophysiology of conditions such as Cushing's disease and depression.
加压素在脑脊液中表现出有节律的每日模式,但在血液中则不然。
DOI: 10.1126/science.7268432
发表时间: 1981
期刊: Science (New York, N.Y.)
影响因子: --
作者:
Reppert,SM;Artman,HG;Swaminathan,S;Fisher,DA
通讯作者: Fisher,DA
DOI: 10.1126/science.6603658
发表时间: 1983-01-01
期刊: SCIENCE
影响因子: 56.9
作者:
ALDENHOFF, JB;GRUOL, DL;SIGGINS, GR
通讯作者: SIGGINS, GR
绵羊促肾上腺皮质激素释放因子给药频率对大鼠促肾上腺皮质激素和皮质酮分泌的影响。
DOI: 10.1210/endo-113-4-1422
发表时间: 1983
期刊: Endocrinology
影响因子: 4.8
作者:
Rivier,C;Vale,W
通讯作者: Vale,W
DOI: 10.1210/endo-113-3-939
发表时间: 1983-01-01
期刊: ENDOCRINOLOGY
影响因子: 4.8
作者:
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通讯作者: VALE, W