ABO blood group is associated with response to inhaled nitric oxide in neonates with respiratory failure.
ABO blood group is associated with response to inhaled nitric oxide in neonates with respiratory failure.
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DOI：
10.1371/journal.pone.0045164
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Ambalavanan N
中科院分区：
文献类型：
--
作者：
El-Ferzli GT;Dreher M;Patel RP;Ambalavanan N
吸入一氧化氮 (iNO) 可减少患有新生儿持续性肺动脉高压 (PPHN) 的婴儿的死亡或体外膜肺氧合 (ECMO) 的需要。然而，对 iNO 的反应各不相同，只有 50-60% 的婴儿表现出对 iNO 的反应。目前尚不清楚为什么只有一些婴儿对 iNO 有反应。 B 型或 AB 型血的成人和儿童对 iNO 的反应不如 O/A 型血的成人和儿童。为了确定血型是否与新生儿的 iNO 反应相关，我们对 2002 年 9 月入住地区 NICU 并诊断为 PPHN 的婴儿进行了回顾性病历审查。数据是在治疗开始后的前十二小时内收集的。在 86 名诊断为 PPHN 的婴儿中，23 名婴儿为 A 型血[18 名接受 iNO]，21 名婴儿为 B 型血[18 名接受 iNO]，40 名婴儿为 O 型血[36 名接受 iNO]，2 名婴儿为 AB 型血[均接受 iNO]。 A 型血婴儿的 PaO2/FiO2 变化较小，其中不到一半的人在 12 小时时有反应（ΔPaO2/FiO2 > 20%），而 O 型或 B 型血婴儿的 PaO2/FiO2 变化为 90%。各组间的种族、性别、出生体重、胎龄、1 分钟和 5 分钟的 Apgar 评分以及基线 PaO2/FiO2 相似。不同血型的结果（包括 ECMO 需求、死亡、通气支持时间、iNO 使用时间和住院时间）在统计学上没有差异。我们的结果表明血型影响新生儿的 iNO 反应。我们假设 ABO 基因位点与血管调节基因存在遗传联系，或者血型抗原直接影响血管反应性。
Inhaled nitric oxide (iNO) reduces death or need for extracorporeal membrane oxygenation (ECMO) in infants with persistent pulmonary hypertension of the newborn (PPHN). However, the response to iNO is variable and only 50–60% of infants demonstrate a response to iNO. It is not known why only some infants respond to iNO. Adults and children with blood groups B or AB do not respond as well to iNO as those with blood groups O/A. To determine if blood group was associated with iNO response in newborn infants, a retrospective medical record review was done of infants admitted to a regional NICU from 2002-9 with a diagnosis of PPHN. Data were collected during the first twelve hours post-initiation of treatment. Of 86 infants diagnosed with PPHN, 23 infants had blood group A [18 received iNO], 21 had group B [18 with iNO], 40 had group O [36 with iNO], and 2 had group AB [both received iNO]. Change in PaO2/FiO2 was less in infants with blood group A, of whom less than half were responders (ΔPaO2/FiO2>20%) at 12 h versus 90% of infants with either O or B. Race, sex, birth weight, gestational age, Apgar scores at 1 and 5 minutes, and baseline PaO2/FiO2 were similar among groups. Outcomes including need for ECMO, death, length of ventilatory support, length of iNO use, and hospital stay were statistically not different by blood groups. Our results indicate that blood group influences iNO response in neonates. We hypothesize that either there is genetic linkage of the ABO gene locus with vasoregulatory genes, or that blood group antigens directly affect vascular reactivity.
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影响因子：
168.9
作者：
Weimann, J;Bauer, H;Zapol, WM
通讯作者：
Zapol, WM
影响因子：
1.7
作者：
Cartron, JP;Colin, Y
通讯作者：
Colin, Y
DOI：
10.1111/j.1538-7836.2008.03243.x
发表时间：
2009-02
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
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通讯作者：
Lumley T
影响因子：
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作者：
Chasman DI;Paré G;Mora S;Hopewell JC;Peloso G;Clarke R;Cupples LA;Hamsten A;Kathiresan S;Mälarstig A;Ordovas JM;Ripatti S;Parker AN;Miletich JP;Ridker PM
通讯作者：
Ridker PM
影响因子：
5.1
作者：
Kinsella, JP;Truog, WE;Abman, SH
通讯作者：
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