ABO genotype and risk of thrombotic events and hemorrhagic stroke.
ABO genotype and risk of thrombotic events and hemorrhagic stroke.
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DOI：
10.1111/j.1538-7836.2008.03243.x
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Lumley T
中科院分区：
文献类型：
--
作者：
Wiggins KL;Smith NL;Glazer NL;Rosendaal FR;Heckbert SR;Psaty BM;Rice KM;Lumley T
ABO基因型的非O等位基因与血栓形成风险增加相关。与特定A1、A2或B等位基因相关的风险尚未明确。探讨ABO基因型与心肌梗死（MI）、缺血性卒中、出血性卒中和静脉血栓形成（VT）的关系。我们使用了2项正在进行的基于人群的MI、卒中和VT病例对照研究的数据。病例包括发生非致死性MI（n=1063）、缺血性卒中（n=469）和出血性卒中（n=91）的高血压成人和绝经后女性，以及发生非致死性VT的绝经后女性（n=504）。对照组的频率与病例的年龄、性别、高血压状态和识别年份相匹配。使用单核苷酸多态性确定ABO基因型，并根据O 1、O2、A11、A2和B等位基因的存在将受试者按二倍型分组。Logistic回归用于检验双体型与每种结局风险的相关性。与O 1 O 1组相比，A11等位基因与VT（比值比[OR] 1.79，95%置信区间：1.41-2.26）和MI（OR 1.23 [1.05-1.44]）风险增加相关。B等位基因与VT（OR 1.82 [1.29-2.57]）和缺血性卒中（OR 1.59 [1.17-2.17]）风险增加相关。AB二倍型类别与VT的2.7倍风险相关（OR 2.70 [1.73-4.21]）。没有其他关联达到显著性。室性心动过速和心肌梗死的结果是确证性的，而B等位基因的缺血性卒中的结果是新的，需要重复。
The non-O alleles of the ABO genotype have been associated with an increased risk of thrombosis. Risk associated with the specific A1, A2, or B alleles is not well defined. To examine the association of ABO genotype with myocardial infarction (MI), ischemic stroke, hemorrhagic stroke, and venous thrombosis (VT). We used data from 2 ongoing population-based case-control studies of MI, stroke, and VT. Cases included hypertensive adults and post-menopausal women with incident non-fatal MI (n=1063), ischemic stroke (n=469), and hemorrhagic stroke (n=91), and postmenopausal women with incident non-fatal VT (n=504). Controls were frequency matched to cases on age, sex, hypertension status, and year of identification. ABO genotypes were determined using single nucleotide polymorphisms and subjects were grouped by diplotype according to the presence of O1, O2, A11, A2, and B alleles. Logistic regression was used to test the association of diplotypes with risk of each outcome. Compared with the O1O1 group, the A11 allele was associated with an increased risk of VT (odds ratio [OR] 1.79, 95% confidence interval: 1.41–2.26) and MI (OR 1.23 [1.05–1.44]). The B allele was associated with an increased risk of VT (OR 1.82 [1.29–2.57]) and ischemic stroke (OR 1.59 [1.17–2.17]). The AB diplotype category was associated with a 2.7-fold risk of VT (OR 2.70 [1.73–4.21]). No other associations reached significance. The VT and MI findings are confirmatory and the ischemic stroke finding with the B allele is a novel and needs replication.
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影响因子：
10.4
作者：
Nossent, A. Y.;Van Marion, V.;Eikenboom, H. C. J.
通讯作者：
Eikenboom, H. C. J.
影响因子：
--
作者：
BRONTESTEWART, B;BOTHA, MC;KRUT, LH
通讯作者：
KRUT, LH
影响因子：
10.4
作者：
Crawley, J. T. B.;Lane, D. A.;Woodward, M.;Rumley, A.;Lowe, G. D. O.
通讯作者：
Lowe, G. D. O.
影响因子：
10.4
作者：
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通讯作者：
Folsom, A. R.
影响因子：
37.8
作者：
Folsom, AR;Rosamond, WD;Wu, KK
通讯作者：
Wu, KK