Immune dysregulation and glucocorticoid resistance in minority and low income pregnant women.
Immune dysregulation and glucocorticoid resistance in minority and low income pregnant women.
复制标题
DOI：
10.1016/j.psyneuen.2013.02.015
复制
发表时间：
2013-09
影响因子：
3.7
通讯作者：
Stafford B
中科院分区：
文献类型：
--
作者：
Corwin EJ;Guo Y;Pajer K;Lowe N;McCarthy D;Schmiege S;Weber M;Pace T;Stafford B
慢性产前压力会导致妇女和婴儿的出生结果不佳。重要的是，不良出生结果在少数族裔和低收入妇女中最为常见。为了研究潜在的机制，我们测试了这样的假设：与少数族裔或低收入状况相关的慢性压力与糖皮质激素抵抗有关，如细胞因子-糖皮质激素反馈回路的破坏所表明的。在此期间进行了家访，妊娠第三个月的孕妇完成了压力和抑郁调查，并提供了促炎和抗炎细胞因子的血液。前一天收集 5 次唾液以检测每日皮质醇水平。为了进行统计分析，女性按照种族、收入以及是否存在这些风险因素分为三类：最后一组被标记为高或低一般风险。通过细胞因子和皮质醇之间功能性负反馈关系的证据来评估免疫调节。在 96 名参与者中，18 名是少数族裔，22 名是低收入人群，29 名是少数族裔或低收入人群（一般风险较高）。 Pearson 偏相关性发现，在低一般风险女性（即白种人、较高收入）中，皮质醇曲线下面积 (AUC) 与促炎细胞因子与抗炎细胞因子比率之间存在显着负相关，包括 IFNγ/IL10 (r = -0.73，p < 0.0001)、IL6/IL10 (r = 0.38，p = 0.01)、IL1β/IL10 (r = -0.44，p = -0.004）和 TNFα/IL10（r = -0.41；p = 0.005）；在一般高危女性（即少数民族、低收入）中，不存在这种相关性（IFNγ/IL10：r = -0.25，p = 0.43；IL6/IL10：r = 0.12，p = 0.70；IL1 β/IL10：r = 0.05，p = 0.87；TNFα/IL10：r = 0.10；p = 0.75），暗示 糖皮质激素抵抗。少数群体和高一般风险群体全天的皮质醇水平也较高（p < 0.05）。如果没有细胞因子糖皮质激素反馈，孕妇调节炎症的能力就会受到限制，可能会导致不良的母婴结局。
Chronic prenatal stress contributes to poor birth outcomes for women and infants. Importantly, poor birth outcomes are most common among minority and low income women. To investigate underlying mechanisms, we tested the hypothesis that chronic stress related to minority or low income status is associated with glucocorticoid resistance as indicated by disruption in the cytokine-glucocorticoid feedback circuit. Home visits were conducted during which 3rd trimester pregnant women completed stress and depression surveys and provided blood for pro- and anti-inflammatory cytokines. Saliva was collected 5 times the preceding day for diurnal cortisol levels. For statistical analyses, women were grouped 3 ways, by race, income, and the presence or absence of either of those risk factors; this last group was labeled high or low general risk. Immune regulation was evaluated by evidence of a functioning negative feedback relationship between cytokines and cortisol. Of 96 participants, 18 were minority, 22 of low income, and 29 either minority or low income (high general risk). Pearson partial correlation identified a significant negative relationship between cortisol area under the curve (AUC) and pro- to anti-inflammatory cytokine ratios in the low general risk women (i.e., Caucasian, higher income) including IFNγ/IL10 (r = −0.73, p < 0.0001), IL6/IL10 (r = 0.38, p = 0.01), IL1β/IL10 (r = −0.44, p = −0.004) and TNFα/IL10 (r = −0.41; p = 0.005); no such correlations existed in the high general risk women (i.e., minority, low income) for (IFNγ/IL10: r = −0.25, p = 0.43; IL6/IL10:r = 0.12, p = 0.70; IL1 β/IL10: r = 0.05, p = 0.87; TNFα/IL10: r = 0.10; p = 0.75), suggestive of glucocorticoid resistance. Cortisol levels throughout the day also were higher in minority and high general risk groups (p < 0.05). Without cytokine glucocorticoid feedback, a pregnant woman’s ability to regulate inflammation is limited, potentially contributing to adverse maternal and infant outcomes.
登录
查看更多内容
DOI：
10.3109/10253890.2011.623250
发表时间：
2011-11
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Buss C;Davis EP;Hobel CJ;Sandman CA
通讯作者：
Sandman CA
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
DOI：
10.1016/j.cppeds.2011.01.001
发表时间：
2011-07
影响因子：
1.6
作者：
Calkins K;Devaskar SU
通讯作者：
Devaskar SU
影响因子：
5.4
作者：
Geronimus, AT
通讯作者：
Geronimus, AT
DOI：
10.1073/pnas.1118355109
发表时间：
2012-04-17
影响因子：
11.1
作者：
Cohen, Sheldon;Janicki-Deverts, Denise;Turner, Ronald B.
通讯作者：
Turner, Ronald B.