The burden of non-communicable disease in transition communities in an Asian megacity: baseline findings from a cohort study in Karachi, Pakistan.
The burden of non-communicable disease in transition communities in an Asian megacity: baseline findings from a cohort study in Karachi, Pakistan.
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DOI：
10.1371/journal.pone.0056008
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Fisher-Hoch SP
中科院分区：
文献类型：
--
作者：
Khan FS;Lotia-Farrukh I;Khan AJ;Siddiqui ST;Sajun SZ;Malik AA;Burfat A;Arshad MH;Codlin AJ;Reininger BM;McCormick JB;Afridi N;Fisher-Hoch SP
南亚人口结构的转变，再加上计划外的城市化和生活方式的改变，正在增加非传染性疾病的负担，在那里传染病仍然非常普遍。这种双重疾病负担的真正规模和影响，尽管预计将是巨大的，但由于缺乏最新的基于人口的纵向数据，在很大程度上是未知的。本研究被设计为一个独特的“弗雷明汉式”巴基斯坦队列，目的是衡量巴基斯坦卡拉奇多民族、中低收入人群中高血压、肥胖症、糖尿病、冠状动脉疾病以及乙型和丙型肝炎感染的患病率和风险因素。我们从一家私立慈善医院的收容人口中选择了两个行政区，随机选择巴基斯坦卡拉奇的队列家庭进行登记。一项基线调查衡量了高血压、肥胖症、糖尿病、冠状动脉疾病以及乙型和丙型肝炎的患病率和危险因素。2010年3月至2011年8月期间，有667户家庭登记。大多数家庭住在永久结构中(85%)，有基本的公共设施(77%)和卫生设施(98%)，但获得清洁饮用水的机会有限(68%)。家庭拥有有线电视(69%)和移动电话(83%)等通信技术的比例很高。吸烟(45%)、超重(20%)、腹型肥胖(53%)、高血压(18%)、糖尿病(8%)和糖尿病前期(40%)等非传染性疾病的危险因素较高。与此同时，乙型肝炎(24%)和丙型肝炎(8%)等传染病在该人群中普遍存在。我们的研究结果强调了在快速城市化和生活方式变化的背景下，通过在高负担过渡社区进行纵向研究来监测风险因素和疾病趋势的必要性。它们还表明了为这些过渡社区量身定做的公共卫生干预计划的紧迫性。
The demographic transition in South Asia coupled with unplanned urbanization and lifestyle changes are increasing the burden of non-communicable disease (NCD) where infectious diseases are still highly prevalent. The true magnitude and impact of this double burden of disease, although predicted to be immense, is largely unknown due to the absence of recent, population-based longitudinal data. The present study was designed as a unique ‘Framingham-like’ Pakistan cohort with the objective of measuring the prevalence and risk factors for hypertension, obesity, diabetes, coronary artery disease and hepatitis B and C infection in a multi-ethnic, middle to low income population of Karachi, Pakistan. We selected two administrative areas from a private charitable hospital’s catchment population for enrolment of a random selection of cohort households in Karachi, Pakistan. A baseline survey measured the prevalence and risk factors for hypertension, obesity, diabetes, coronary artery disease and hepatitis B and C infection. Six hundred and sixty-seven households were enrolled between March 2010 and August 2011. A majority of households lived in permanent structures (85%) with access to basic utilities (77%) and sanitation facilities (98%) but limited access to clean drinking water (68%). Households had high ownership of communication technologies in the form of cable television (69%) and mobile phones (83%). Risk factors for NCD, such as tobacco use (45%), overweight (20%), abdominal obesity (53%), hypertension (18%), diabetes (8%) and pre-diabetes (40%) were high. At the same time, infectious diseases such as hepatitis B (24%) and hepatitis C (8%) were prevalent in this population. Our findings highlight the need to monitor risk factors and disease trends through longitudinal research in high-burden transition communities in the context of rapid urbanization and changing lifestyles. They also demonstrate the urgency of public health intervention programs tailored for these transition communities.
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2.2
作者：
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通讯作者：
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DOI：
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