Implication of atypical supraclavicular F18-fluorodeoxyglucose uptake in patients with breast cancer: Association between brown adipose tissue and breast cancer.
Implication of atypical supraclavicular F18-fluorodeoxyglucose uptake in patients with breast cancer: Association between brown adipose tissue and breast cancer.
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乳腺癌患者中非典型上锁骨上F18-氟脱氧葡萄糖摄取的含义：棕色脂肪组织与乳腺癌之间的关联。
DOI：
10.3892/ol.2017.6768
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发表时间：
2017-12
期刊：
影响因子：
2.9
通讯作者：
Kuwano H
中科院分区：
文献类型：
--
作者：
Fujii T;Yajima R;Tatsuki H;Oosone K;Kuwano H
据报道，颈部和锁骨上病变中的F18-氟脱氧葡萄糖（FDG）摄取代表活化的棕色脂肪组织（BAT）。在本研究中，BAT活性，检测FDG-正电子发射断层扫描（PET），与乳腺癌患者的临床病理特征之间的关联进行了研究。分析了156例乳腺癌患者术前进行FDG-PET检查的病例。我们回顾了颈部和/或锁骨上区不典型FDG摄取的分布和强度。强度分级如下：1，弱; 2，中度; 3，强烈。在156例患者中，70例（44.9%）显示1级强度，65例（41.7%）显示2级强度，21例（13.5%）显示3级强度。FDG强度与人表皮生长因子受体2（HER 2）表达和孕酮表达显著相关。156例患者中，6例（3.8%）复发。多因素分析显示，低级别的非典型FDG摄取是短期复发的唯一独立危险因素，复发性疾病患者均未出现可能反映BAT激活的非典型FDG摄取。这些结果表明，BAT的存在与HER 2表达相关，BAT的缺失可能是乳腺癌的预后因素。
It has been reported that F18-fluorodeoxyglucose (FDG) uptake in the neck and supraclavicular lesions represents activated brown adipose tissue (BAT). In the present study, the association between BAT activity, detected by FDG-positron emission tomography (PET), and the clinicopathological features of patients with breast cancer was investigated. The cases of 156 consecutive patients with breast cancer who underwent FDG-PET preoperatively were analyzed. The distribution and intensity of atypical FDG uptake in the neck and/or supraclavicular region was reviewed. The intensity was graded as follows: 1, weak; 2, moderate; and 3, intense. Among the 156 patients, 70 (44.9%) exhibited grade 1 intensity, 65 (41.7%) exhibited grade 2 intensity and 21 (13.5%) exhibited grade 3 intensity. The intensity of FDG was significantly associated with human epidermal growth factor receptor 2 (HER2) expression and progesterone expression. Among the 156 patients, 6 (3.8%) had recurrent disease. Multivariate analysis revealed that showing a low grade of atypical FDG uptake was the only independent risk factor of short-term recurrence, and none of the patients with recurrent disease had atypical FDG uptake that may reflect the activation of BAT. These results indicated that the presence of BAT is associated with HER2 expression and the absence of BAT may be a prognostic factor for breast cancer.
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影响因子：
4.5
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影响因子：
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