Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases.
Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases.
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α7烟碱受体是基于炎症疾病的新型治疗靶标。
DOI：
10.1007/s00018-010-0525-1
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发表时间：
2011-03
影响因子：
8
通讯作者：
Marrero, Mario B.
中科院分区：
文献类型：
--
作者：
Bencherif, Merouane;Lippiello, Patrick M.;Lucas, Rudolf;Marrero, Mario B.
近年来，许多使人衰弱的疾病，如2型糖尿病、关节炎、动脉粥样硬化、牛皮癣、哮喘、囊性纤维化、败血症和溃疡性结肠炎的病因病理越来越多地与失控的细胞因子介导的炎症有关。基于细胞因子的治疗剂在这些疾病的治疗中起着重要作用。然而，各种细胞因子的时空变化仍然知之甚少，迄今为止的尝试主要集中在抑制特定细胞因子如TNF-α。作为一种替代方法，许多临床前研究已经证实了通过调节促炎细胞因子靶向α 7烟碱乙酰胆碱受体介导的抗炎作用的治疗潜力。这种“胆碱能抗炎途径”通过胆碱能机制作用于巨噬细胞和免疫细胞上表达的alpha7受体来调节免疫系统。如果临床前研究结果转化为人类疗效，这种方法可能为治疗一系列顽固性疾病和炎症成分的病症提供新的治疗方法。
In recent years the etiopathology of a number of debilitating diseases such as type 2 diabetes, arthritis, atherosclerosis, psoriasis, asthma, cystic fibrosis, sepsis, and ulcerative colitis has increasingly been linked to runaway cytokine-mediated inflammation. Cytokine-based therapeutic agents play a major role in the treatment of these diseases. However, the temporospatial changes in various cytokines are still poorly understood and attempts to date have focused on the inhibition of specific cytokines such as TNF-α. As an alternative approach, a number of preclinical studies have confirmed the therapeutic potential of targeting alpha7 nicotinic acetylcholine receptor-mediated anti-inflammatory effects through modulation of proinflammatory cytokines. This “cholinergic anti-inflammatory pathway” modulates the immune system through cholinergic mechanisms that act on alpha7 receptors expressed on macrophages and immune cells. If the preclinical findings translate into human efficacy this approach could potentially provide new therapies for treating a broad array of intractable diseases and conditions with inflammatory components.
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影响因子：
4.4
作者：
Devaraj S;Singh U;Jialal I
通讯作者：
Jialal I
影响因子：
5.7
作者：
Dowling, Oonagh;Rochelson, Burton;Metz, Christine N.
通讯作者：
Metz, Christine N.
影响因子：
6.4
作者：
Erdman, Susan E.;Rao, Varada P.;Olipitz, Werner;Taylor, Christie L.;Jackson, Erin A.;Levkovich, Tatiana;Lee, Chung-Wei;Horwitz, Bruce H.;Fox, James G.;Ge, Zhongming;Poutahidis, Theofilos
通讯作者：
Poutahidis, Theofilos
DOI：
10.1038/oby.2003.74
发表时间：
2003-04-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Bulló, M;García-Lorda, P;Salas-Salvadó, J
通讯作者：
Salas-Salvadó, J
影响因子：
5.6
作者：
Chernyavsky, Alexander I.;Arredondo, Juan;Grando, Sergei A.
通讯作者：
Grando, Sergei A.