Engineering synthetic hydrogel microenvironments to instruct stem cells.
Engineering synthetic hydrogel microenvironments to instruct stem cells.
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DOI：
10.1016/j.copbio.2013.03.009
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发表时间：
2013-10
影响因子：
7.7
通讯作者：
Burdick, Jason A.
中科院分区：
文献类型：
--
作者：
Guvendiren, Murat;Burdick, Jason A.
我们对干细胞行为的理解和操纵能力的进步有助于将基于干细胞的治疗推向临床。然而，我们的大部分知识都是从标准的2维培养系统中获得的，这些系统经常歪曲干细胞在其天然3维环境中接收的许多信号。幸运的是，合成水凝胶领域正在发展，以更好地概括许多这些信号，以指导干细胞的行为，既作为体外模型，也作为体内植入的递送载体。这些包括大量的结构和生化线索，可以在细胞尺度上，如降解，粘附，机械信号，地形，和生长因子的介绍，往往与精确的时空控制。
Advances in our understanding and ability to manipulate stem cell behavior are helping to move stem cell-based therapies toward the clinic. However, much of our knowledge has been gained from standard 2-dimensional culture systems, which often misrepresent many of the signals that stem cells receive in their native 3-dimensional environments. Fortunately, the field of synthetic hydrogels is developing to better recapitulate many of these signals to guide stem cell behavior, both as in vitro models and as delivery vehicles for in vivo implantation. These include a multitude of structural and biochemical cues that can be presented on the cellular scale, such as degradation, adhesion, mechanical signals, topography, and the presentation of growth factors, often with precise spatiotemporal control.
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影响因子：
7.7
作者：
Jabbari, Esmaiel
通讯作者：
Jabbari, Esmaiel
影响因子：
14
作者：
Bian, Liming;Zhai, David Y.;Tous, Elena;Rai, Reena;Mauck, Robert L.;Burdick, Jason A.
通讯作者：
Burdick, Jason A.
影响因子：
14
作者：
Kisiel, Marta;Martino, Mikael M.;Ossipov, Dmitri A.
通讯作者：
Ossipov, Dmitri A.
影响因子：
14
作者：
Kim, Iris L.;Mauck, Robert L.;Burdick, Jason A.
通讯作者：
Burdick, Jason A.
影响因子：
6.2
作者：
Elbert, DL;Hubbell, JA
通讯作者：
Hubbell, JA