Hydrogel design for cartilage tissue engineering: a case study with hyaluronic acid.
Hydrogel design for cartilage tissue engineering: a case study with hyaluronic acid.
复制标题
DOI：
10.1016/j.biomaterials.2011.08.073
复制
发表时间：
2011-12
期刊：
影响因子：
14
通讯作者：
Burdick, Jason A.
中科院分区：
文献类型：
--
作者：
Kim, Iris L.;Mauck, Robert L.;Burdick, Jason A.
在承重的腹股沟关节中，透明软骨用作低摩擦和耐磨的关节表面。不幸的是，由于软骨的无血管、麻木性质严重阻碍了身体的自然再生能力，创伤和骨关节炎造成的损伤需要尝试修复。目前的临床方法通常在再生功能性软骨的能力方面受到限制，因此近年来的研究集中在组织工程解决方案上，其中通过将细胞(例如软骨细胞或干细胞)与支架(例如水凝胶、海绵和网状物)以及刺激生长因子和生物反应器相结合来实现软骨的再生。使用了各种合成和天然材料，最常见的形式是水凝胶，这些系统已经进行了调整，以实现最佳的营养扩散、沉积基质的连通性、降解、可溶性因子输送和机械加载，以增强基质的生产和组织。尽管有了这些有希望的进展，但天然软骨的复杂力学性能和生化组成还没有达到，工程软骨组织仍然是一个巨大的挑战。本文以透明质酸水凝胶为例，对软骨组织工程材料设计的进展进行了综述，并提出了该领域未来可能的研究方向。
Hyaline cartilage serves as a low-friction and wear-resistant articulating surface in load-bearing, diarthrodial joints. Unfortunately, as the avascular, alymphatic nature of cartilage significantly impedes the body’s natural ability to regenerate, damage resulting from trauma and osteoarthritis necessitates repair attempts. Current clinical methods are generally limited in their ability to regenerate functional cartilage, and so research in recent years has focused on tissue engineering solutions in which the regeneration of cartilage is pursued through combinations of cells (e.g., chondrocytes or stem cells) paired with scaffolds (e.g., hydrogels, sponges, and meshes) in conjunction with stimulatory growth factors and bioreactors. A variety of synthetic and natural materials have been employed, most commonly in the form of hydrogels, and these systems have been tuned for optimal nutrient diffusion, connectivity of deposited matrix, degradation, soluble factor delivery, and mechanical loading for enhanced matrix production and organization. Even with these promising advances, the complex mechanical properties and biochemical composition of native cartilage have not been achieved, and engineering cartilage tissue still remains a significant challenge. Using hyaluronic acid hydrogels as an example, this review will follow the progress of material design specific to cartilage tissue engineering and propose possible future directions for the field.
登录
查看更多内容
影响因子：
14
作者：
Bian, Liming;Zhai, David Y.;Tous, Elena;Rai, Reena;Mauck, Robert L.;Burdick, Jason A.
通讯作者：
Burdick, Jason A.
影响因子：
14
作者：
Chung, Cindy;Beecham, Michael;Mauck, Robert L.;Burdick, Jason A.
通讯作者：
Burdick, Jason A.
影响因子：
--
作者：
Chung, Cindy;Mesa, John;Burdick, Jason A.
通讯作者：
Burdick, Jason A.
影响因子：
14
作者：
Awad, HA;Wickham, MQ;Guilak, F
通讯作者：
Guilak, F
影响因子：
2.8
作者：
Angele, P;Yoo, JU;Johnstone, B
通讯作者：
Johnstone, B