Muscle oxygenation measurement in humans by noninvasive optical spectroscopy and Locally Weighted Regression.
Muscle oxygenation measurement in humans by noninvasive optical spectroscopy and Locally Weighted Regression.
复制标题
DOI：
10.1016/j.aca.2013.05.003
复制
发表时间：
2013-06-27
影响因子：
6.2
通讯作者：
Shaver JM
中科院分区：
文献类型：
--
作者：
Arakaki LS;Schenkman KA;Ciesielski WA;Shaver JM
我们开发了一种方法，可以从皮肤表面实时、连续、无创地测量肌肉氧合（Mox）。一个关键的发展是在可见光和近红外（NIR）区域的测量。氧合和脱氧肌红蛋白和血红蛋白的测量导致更准确的测量Mox比可以实现与仅脱氧成分的测量，如在传统的近红外光谱（NIRS）。使用相对于波长的二阶导数减少了散射对光谱的影响，并且还使得含氧和脱氧形式彼此更可区分。选择含氧和脱氧形式吸收滤除噪声和与混合氧化物无关的光谱特征的光谱带。将NIR和可见条带相对于彼此缩放，以校正由归一化引入的误差。使用多变量曲线分辨率（MCR）从健康受试者收集的每个数据集内的光谱估计Mox。局部加权回归（LWR）模型建立从校准集光谱和相关的Mox值从20个科目使用2562光谱。LWR和偏最小二乘法（PLS）允许准确测量Mox，尽管不同受试者的皮肤色素或脂肪层厚度存在差异。该方法估计了5名健康受试者的Mox，RMSE为5.4%。
We have developed a method to make real-time, continuous, noninvasive measurements of muscle oxygenation (Mox) from the surface of the skin. A key development was measurement in both the visible and near infrared (NIR) regions. Measurement of both oxygenated and deoxygenated myoglobin and hemoglobin resulted in a more accurate measurement of Mox than could be achieved with measurement of only the deoxygenated components, as in traditional near-infrared spectroscopy (NIRS). Using the second derivative with respect to wavelength reduced the effects of scattering on the spectra and also made oxygenated and deoxygenated forms more distinguishable from each other. Selecting spectral bands where oxygenated and deoxygenated forms absorb filtered out noise and spectral features unrelated to Mox. NIR and visible bands were scaled relative to each other in order to correct for errors introduced by normalization. Multivariate Curve Resolution (MCR) was used to estimate Mox from spectra within each data set collected from healthy subjects. A Locally Weighted Regression (LWR) model was built from calibration set spectra and associated Mox values from 20 subjects using 2562 spectra. LWR and Partial Least Squares (PLS) allow accurate measurement of Mox despite variations in skin pigment or fat layer thickness in different subjects. The method estimated Mox in five healthy subjects with an RMSE of 5.4%.
登录
查看更多内容
DOI：
10.1152/ajpheart.00192.2003
发表时间：
2003-11-01
影响因子：
4.8
作者：
Marcinek, DJ;Ciesielski, WA;Schenkman, KA
通讯作者：
Schenkman, KA
影响因子：
2.4
作者：
Van Benthem, MH;Keenan, MR;Haaland, DM
通讯作者：
Haaland, DM
影响因子：
9.8
作者：
Murkin, J M;Arango, M
通讯作者：
Arango, M
影响因子：
7.4
作者：
SAVITZKY, A;GOLAY, MJE
通讯作者：
GOLAY, MJE
影响因子：
4.2
作者：
Cohen, Gordon A.;Permut, Lester C.;Schenkman, Kenneth A.
通讯作者：
Schenkman, Kenneth A.