Forgotten fungi: the importance of the skin mycobiome.

Forgotten fungi: the importance of the skin mycobiome.
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DOI:
10.1016/j.mib.2022.102235
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发表时间:
2022-12
影响因子:
5.4
通讯作者:
Kalan, Lindsay R.
Kalan, Lindsay R.
中科院分区:
生物学2区
文献类型:
--
作者:
Nguyen, Uyen Thy;Kalan, Lindsay R.

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生活在我们皮肤上的微生物马赛克生态系统不仅包括细菌,还包括真菌,微真核生物和病毒。作为第二个最普遍的群体,在人类皮肤的干燥,潮湿和油性微环境中发现了独特的真菌群落,这些群落的变化主要是由个体一生中皮肤生理学的变化驱动的。真菌也与感染和皮肤病有关,这是由于皮肤上真菌-细菌网络之间的平衡被破坏。动物皮肤微生物组中对真菌的定殖抗性机制促进了我们对保护策略的理解,但在人类皮肤中,真菌微生物组(真菌菌群)仍然是未被探索的。在这里,我们回顾了最近关于真菌在皮肤微生物组中的作用的研究,强调皮肤表面的真菌-细菌相互作用如何在脊椎动物宿主中发挥重要的生态功能。
The mosaic ecosystems of microbes that live on our skin encompasses not only bacteria but also fungi, microeukaryotes, and viruses. As the second most prevalent group, unique fungal communities are found across the dry, moist, and oily microenvironments of human skin, and alterations of these communities is largely driven by changes in skin physiology throughout an individual’s lifespan. Fungi have also been associated with infection and dermatological disorders, resulting from the disrupted balance between fungal-bacterial networks on the skin. Mechanisms of colonization resistance towards fungi in the skin microbiome of animals have advanced our understanding in conservation strategies yet in the human skin, the fungal microbiome (mycobiome) remains vastly unexplored. Here, we review recent studies on the role of fungi in the skin microbiome, emphasizing how fungal-bacterial interactions at the skin surface play an important ecological function in vertebrate hosts.
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