Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes.
Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes.
复制标题
组织蛋白酶 D 增加与新诊断 2 型糖尿病的临床参数相关。
DOI：
10.1155/2017/5286408
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Wang DW
中科院分区：
文献类型：
--
作者：
Liu L;Chen B;Zhang X;Tan L;Wang DW
组织蛋白酶D最近被认为与胰岛素抵抗和心血管疾病有关。本研究旨在探讨组织蛋白酶D与新诊断的2型糖尿病之间的关系。测量了98例患者和98例对照组的循环组织蛋白酶D水平和代谢变量。用多普勒超声心动图测量反映左心室收缩和舒张功能的心肌功能指数Tei指数。新诊断的2型糖尿病患者的循环组织蛋白酶D浓度明显高于对照组（中位水平：227 ng/ml vs 174 ng/ml， P < 0.01）。在新诊断的2型糖尿病患者中，组织蛋白酶D水平与HOMA-IR（胰岛素抵抗的稳态模型评估）之间存在显著相关性（r = 0.25, P = 0.01）。对照组组织蛋白酶D水平与临床参数无显著相关性（P < 0.05）。有趣的是，相关分析显示2型糖尿病患者组织蛋白酶D水平与Tei指数呈正相关（r = 0.22, P = 0.03）。循环组织蛋白酶D水平的升高与2型糖尿病的存在密切相关，组织蛋白酶D可能作为新诊断的2型糖尿病患者心功能障碍的一种新的生物标志物。
Cathepsin D has been recently implicated in insulin resistance and cardiovascular disease. This study was designed to investigate the relationship between cathepsin D and newly diagnosed type 2 diabetes. Circulating cathepsin D levels and metabolic variables were measured in 98 cases and 98 controls. Myocardial performance index “Tei index” that reflects both left ventricular systolic and diastolic function was measured with Doppler echocardiography in cases. Newly diagnosed type 2 diabetes demonstrated significantly higher circulating cathepsin D concentrations than controls (median level: 227 ng/ml versus 174 ng/ml, P < 0.01). In newly diagnosed type 2 diabetes, a significant correlation was found between cathepsin D levels and HOMA-IR (homeostatic model assessment of insulin resistance) (r = 0.25, P = 0.01). In contrast, no significant correlation was found between cathepsin D levels and clinical parameters in the control group (all P > 0.05). Interestingly, correlation analysis revealed a positive association between cathepsin D levels and Tei index in type 2 diabetes (r = 0.22, P = 0.03). Increased levels of circulating cathepsin D are closely linked with the presence of type 2 diabetes, and cathepsin D might serve as a novel biomarker for cardiac dysfunction in newly diagnosed type 2 diabetes.
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