The schistosoma granuloma: friend or foe?
The schistosoma granuloma: friend or foe?
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DOI：
10.3389/fimmu.2013.00089
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发表时间：
2013
影响因子：
7.3
通讯作者：
Fallon PG
中科院分区：
文献类型：
--
作者：
Hams E;Aviello G;Fallon PG
人感染血吸虫属吸虫寄生虫可引起显著的慢性发病率。感染血吸虫的个体可能会发展出一系列病理学，从轻度尾蚴性皮炎到严重的组织炎症，特别是在肝脏和肠道内，这可能导致危及生命的肝脾肿大。血吸虫病的发病机制主要是由于对寄生虫的过度或不受调节的炎症反应，特别是对被困在各种组织中的虫卵的炎症反应。虫卵形成典型的2型肉芽肿性炎症病灶，其特征为嗜酸性粒细胞丰富、CD4+辅助性T（Th）2细胞为主的浸润，伴有替代性活化巨噬细胞（M2）的额外浸润。事实上，2型卵圆周肉芽肿的后遗症是明显的成纤维细胞浸润和纤维化的发展。奇怪的是，虽然肉芽肿是病理的原因，但它也可以提供一些保护，从而肉芽肿使肝脏和肠道中的附带组织损伤最小化。此外，寄生虫非常依赖宿主对虫卵产生肉芽肿反应，因为这种炎症反应有助于虫卵从宿主体内成功排出。在这篇集中的评论中，我们将解决S。曼氏肉芽肿在感染过程中对炎症的作用是敌是友。
Infection of man with Schistosoma species of trematode parasite causes marked chronic morbidity. Individuals that become infected with Schistosomes may develop a spectrum of pathology ranging from mild cercarial dermatitis to severe tissue inflammation, in particular within the liver and intestines, which can lead to life threatening hepatosplenomegaly. It is well established that the etiopathology during schistosomiasis is primarily due to an excessive or unregulated inflammatory response to the parasite, in particular to eggs that become trapped in various tissue. The eggs forms the foci of a classical type 2 granulomatous inflammation, characterized by an eosinophil-rich, CD4+ T helper (Th) 2 cell dominated infiltrate with additional infiltration of alternatively activated macrophages (M2). Indeed the sequela of the type 2 perioval granuloma is marked fibroblast infiltration and development of fibrosis. Paradoxically, while the granuloma is the cause of pathology it also can afford some protection, whereby the granuloma minimizes collateral tissue damage in the liver and intestines. Furthermore, the parasite is exquisitely reliant on the host to mount a granulomatous reaction to the eggs as this inflammatory response facilitates the successful excretion of the eggs from the host. In this focused review we will address the conundrum of the S. mansoni granuloma acting as both friend and foe in inflammation during infection.
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DOI：
10.4269/ajtmh.1997.56.515
发表时间：
1997-05-01
影响因子：
3.3
作者：
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通讯作者：
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DOI：
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影响因子：
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发表时间：
2000-01-01
期刊：
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影响因子：
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作者：
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影响因子：
2.4
作者：
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