Ultrasonic-activated micellar drug delivery for cancer treatment.
Ultrasonic-activated micellar drug delivery for cancer treatment.
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DOI：
10.1002/jps.21444
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发表时间：
2009-03
影响因子：
3.8
通讯作者：
Pitt, William G.
中科院分区：
文献类型：
--
作者：
Husseini, Ghaleb A.;Pitt, William G.
纳米粒子和超声波在医学中的应用不断发展。在生产可用于药物递送的胶束、纳米乳剂和固体纳米颗粒方面已经取得了长足的进步。有效的纳米载体允许将高浓度的强效药物递送到靶向组织，同时最大限度地减少药剂对身体其他部位的副作用。聚合物胶束已被证明可以包封治疗剂并在较低浓度下保持其结构完整性。超声目前被用于药物输送以及诊断，并且具有许多优点，这些优点提高了其在药物输送中的重要性。该技术是非侵入性的，因此不需要手术;超声波可以很容易地通过先进的电子技术控制，使它们可以集中在所需的目标体积。此外，超声波的物理学被广泛使用和很好地理解;因此，超声波应用可以针对特定的药物输送系统进行定制。本文综述了近年来聚合物胶束与超声联合给药的研究进展。
The use of nanoparticles and ultrasound in medicine continues to evolve. Great strides have been made in the areas of producing micelles, nanoemulsions and solid nanoparticles that can be used in drug delivery. An effective nanocarrier allows for the delivery of a high concentration of potent medications to targeted tissue while minimizing the side effect of the agent to the rest of the body. Polymeric micelles have been shown to encapsulate therapeutic agents and maintain their structural integrity at lower concentrations. Ultrasound is currently being used in drug delivery as well as diagnostics, and has many advantages that elevate its importance in drug delivery. The technique is non-invasive, thus no surgery is needed; the ultrasonic waves can be easily controlled by advanced electronic technology so that they can be focused on the desired target volume. Additionally, the physics of ultrasound are widely used and well understood; thus ultrasonic application can be tailored towards a particular drug delivery system. In this article, we review the recent progress made in research that utilizes both polymeric micelles and ultrasonic power in drug delivery.
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影响因子：
3.9
作者：
ALEXANDRIDIS, P;ATHANASSIOU, V;HATTON, TA
通讯作者：
HATTON, TA
影响因子：
2.9
作者：
DANIELS, S;BLONDEL, D;DYSON, M
通讯作者：
DYSON, M
影响因子：
3.7
作者：
BOMMANNAN, D;OKUYAMA, H;GUY, RH
通讯作者：
GUY, RH
影响因子：
5.5
作者：
ALEXANDRIDIS, P;HOLZWARTH, JF;HATTON, TA
通讯作者：
HATTON, TA
影响因子：
9.7
作者：
FAIRBAIRN, JJ;KHAN, MW;ONEILL, KL
通讯作者：
ONEILL, KL