Lubricin in experimental and naturally occurring osteoarthritis: a systematic review.
Lubricin in experimental and naturally occurring osteoarthritis: a systematic review.
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DOI：
10.1016/j.joca.2020.05.009
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发表时间：
2020-10
影响因子：
7
通讯作者：
Reesink HL
中科院分区：
文献类型：
--
作者：
Watkins AR;Reesink HL
在创伤后和自然发生的骨关节炎研究中，润滑素越来越多地被评估为一种结局指标。然而，结果存在差异，因此不清楚骨关节炎中润滑素是否增加，减少或不变。本研究的目的是回顾所有测量关节损伤或骨关节炎中润滑素的论文，以得出有关关节疾病中润滑素调节的结论。对Pubmed、Web of Knowledge和EBSCOhost数据库中的论文进行了系统检索。纳入标准是在体内研究，测量润滑素在人类或动物关节损伤，研究润滑素补充骨关节炎关节，或描述的表型的润滑素敲除模型。进行了方法学评估。纳入了62项研究，其中38项测量了关节损伤或骨关节炎中的内源性润滑素。19篇论文发现润滑素增加或无变化，19篇报告减少。报告润滑素减少的论文被引用的次数是报告增加的论文的四倍。15篇论文描述了润滑素补充剂，并且都报道了有益的效果。11篇论文描述了润滑素敲除模型。人类文献显示，报告骨关节炎中润滑素升高与润滑素降低的论文分布相似。动物文献主要报道大鼠前交叉韧带横断模型中润滑素减少，而大型动物模型中的研究报告润滑素增加。关节内补充润滑素可能是有益的，无论润滑素在OA中是增加还是减少。
Lubricin is increasingly being evaluated as an outcome measure in studies investigating posttraumatic and naturally occurring osteoarthritis. However, there are discrepancies in results, making it unclear as to whether lubricin is increased, decreased or unchanged in osteoarthritis. The purpose of this study was to review all papers that measured lubricin in joint injury or osteoarthritis in order to draw conclusions about lubricin regulation in joint disease. A systematic search of the Pubmed, Web of Knowledge, and EBSCOhost databases for papers was performed. Inclusion criteria were in vivo studies that measured lubricin in humans or animals with joint injury, that investigated lubricin supplementation in osteoarthritic joints, or that described the phenotype of a lubricin knock-out model. A methodological assessment was performed. Sixty-two studies were included, of which thirty-eight measured endogenous lubricin in joint injury or osteoarthritis. Nineteen papers found an increase or no change in lubricin and nineteen reported a decrease. Papers that reported a decrease in lubricin were cited four times more often than those that reported an increase. Fifteen papers described lubricin supplementation, and all reported a beneficial effect. Eleven papers described lubricin knock-out models. The human literature reveals similar distributions of papers reporting increased lubricin as compared to decreased lubricin in osteoarthritis. The animal literature is dominated by reports of decreased lubricin in the rat anterior cruciate ligament transection model, whereas studies in large animal models report increased lubricin. Intra-articular lubricin supplementation may be beneficial regardless of whether lubricin increases or decreases in OA.
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影响因子：
--
作者：
Antonacci, Jennifer M.;Schmidt, Tannin A.;Serventi, Lisa A.;Cai, Matthew Z.;Shu, Yuyu L.;Schumacher, Barbara L.;McIlwraith, C. Wayne;Sah, Robert L.
通讯作者：
Sah, Robert L.
影响因子：
3.7
作者：
Ai M;Cui Y;Sy MS;Lee DM;Zhang LX;Larson KM;Kurek KC;Jay GD;Warman ML
通讯作者：
Warman ML
影响因子：
--
作者：
Drewniak, Elizabeth I.;Jay, Gregory D.;Crisco, Joseph J.
通讯作者：
Crisco, Joseph J.
影响因子：
4.1
作者：
Estrella, Ruby P.;Whitelock, John M.;Karlsson, Niclas G.
通讯作者：
Karlsson, Niclas G.
影响因子：
5.3
作者：
Chu, Constance R.;Millis, Michael B.;Olson, Steven A.
通讯作者：
Olson, Steven A.