Developing home cleaning intervention through community engagement to reduce infections and antimicrobial resistance in Ghanaian homes.
Developing home cleaning intervention through community engagement to reduce infections and antimicrobial resistance in Ghanaian homes.
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DOI：
10.1038/s41598-023-37317-4
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发表时间：
2023-06-28
影响因子：
4.6
通讯作者：
Darby, Andy
中科院分区：
文献类型：
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作者：
Tsekleves, Emmanuel;de Souza, Dziedzom;Pickup, Roger;Ahorlu, Collins;Darby, Andy
在全球范围内，抗微生物药物耐药性（AMR）构成了一种健康危机，特别是在传染病通常致命的发展中国家。有明确的证据表明，家中存在微生物接触和感染传播。个人和环境卫生是减少家庭感染的最佳途径，从而减少对抗生素的需求，从而减少抗生素耐药性。尽管这是一个明显的步骤，但了解家庭环境及其对AMR，清洁和可能的家庭清洁干预措施的影响的研究努力是有限的。我们以一种创新的混合方法将设计和微生物学方法结合起来。进行了传统的调查设计（n = 240），设计人种学（n = 12），共同设计研讨会和干预前微生物粉尘样本分析，为共同设计研讨会提供见解，在这些研讨会中可以开发新的清洁方法，以最大限度地减少加纳大阿克拉地区家庭环境中存在的任何AMR细菌。家用粉尘的微生物学分析显示，发现36.6%的检出细菌分离株对所测抗生素组至少携带一种耐药性。从调查数据的经济细分中产生了四种情景。在共同设计研讨会上，“提出”了50个人种学见解，并向参与者介绍了对一种或多种抗生素具有耐药性的12种细菌物种（代表对灰尘样本中发现的一种或多种抗生素具有耐药性的176种细菌分离株）的描述。在（n = 7）个家庭中进行了一项干预措施，即通过共同设计研讨会商定的一种新的清洁实践制度，并进行了30天的实践。本研究中观察到的多药耐药的高流行率表明，不仅在医院环境中，而且在家庭环境中，都需要抗生素监测计划。因此，迫切需要在家庭一级确定干预措施的目标。通过社区参与研究来激活知识，有助于提高公众认知，打破科学家与公众之间的障碍。
Globally Antimicrobial Resistance (AMR) constitutes a health crisis, particularly in developing countries, where infectious disease are commonly fatal. There is clear evidence for microbial exposure and infection transmission within the home. Personal and environmental hygiene are the best ways of reducing household infections thus decreasing the need for antibiotics and consequently diminishing AMR. Despite this being an obvious step, research efforts to understand the home environment and its impact on AMR, cleaning and possible interventions on household cleaning are limited. We combined design and microbiology methods in an innovative mixed-method approach. A traditional survey design (n = 240), a design ethnography (n = 12), a co-design workshop and a pre-intervention microbiological dust sample analysis was undertaken to provide insights for codesign workshops in which new cleaning practices might be developed to minimise any AMR bacteria present in the household environments located in the Greater Accra Region of Ghana. Microbiological analysis of household dust showed that 36.6% of bacterial isolates detected were found to carry at least one resistance to the panel of antibiotics tested. Four scenarios were generated from an economic segmentation of the survey data. 50 ethnographic insights were ‘presented’ and descriptions of 12 bacteria species that showed resistance to one or more antibiotics (representing 176 bacterial isolates that showed resistance to one or more antibiotics found in the dust samples) were presented to the participants in a codesign workshop. An intervention, a new regime of cleaning practices agreed through the co-design workshop and practiced for thirty days, was made in (n = 7) households. The high prevalence of multidrug resistance observed in this study indicate the need for antibiotics surveillance program, not only in hospital settings but also in the household environment. There is, thus, an urgent need for targeting of interventions at the household level. Activating knowledge through community engagement in the research helps in increasing public perception and breaking down the scientist-public barrier.
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影响因子：
3.3
作者：
Godoy-Ruiz P;Cole DC;Lenters L;McKenzie K
通讯作者：
McKenzie K
影响因子：
5.4
作者：
Curtis, V;Biran, A;Drasar, B
通讯作者：
Drasar, B
影响因子：
11.8
作者：
Ding, Long-Jun;Zhou, Xin-Yuan;Zhu, Yong-Guan
通讯作者：
Zhu, Yong-Guan
DOI：
10.1080/0960312031000102859
发表时间：
2003-06-01
影响因子：
3.2
作者：
Duse, AG;da Silva, MP;Zietsman, I
通讯作者：
Zietsman, I
DOI：
10.1111/j.1365-2222.2006.02463.x
发表时间：
2006-04
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
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作者：
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