The Argo: a high channel count recording system for neural recording in vivo.
The Argo: a high channel count recording system for neural recording in vivo.
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Argo：用于体内神经记录的高通道计数记录系统。
DOI：
10.1088/1741-2552/abd0ce
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发表时间：
2021-02-24
影响因子：
4
通讯作者：
Angle MR
中科院分区：
文献类型：
--
作者：
Sahasrabuddhe K;Khan AA;Singh AP;Stern TM;Ng Y;Tadić A;Orel P;LaReau C;Pouzzner D;Nishimura K;Boergens KM;Shivakumar S;Hopper MS;Kerr B;Hanna MS;Edgington RJ;McNamara I;Fell D;Gao P;Babaie-Fishani A;Veijalainen S;Klekachev AV;Stuckey AM;Luyssaert B;Kozai TDY;Xie C;Gilja V;Dierickx B;Kong Y;Straka M;Sohal HS;Angle MR
解码神经活动受到缺乏工具的限制，这些工具可用于同时以高时间保真度记录跨多个皮层区域的大量神经元。为此，我们开发了Argo系统，以高数据速率记录皮层神经活动。在这里，我们展示了一个大规模并行神经记录系统的基础上，铂铱微丝电极阵列键合到CMOS电压放大器阵列。Argo系统是通道数最多的体内神经记录系统，支持65，536个通道的同时记录，以32 kHz和12位分辨率采样。该系统设计用于皮层记录，与穿透和表面微电极兼容。我们验证了这个系统，通过初步的实验室测试，以确定特定的增益和噪声特性的键合微丝，然后在大鼠和绵羊皮层的体内实验。我们记录了大鼠791个神经元的尖峰活动和绵羊30，000多个通道的表面LFP活动。这是大鼠和绵羊中最大的通道计数基于微丝的记录。虽然目前适用于头部固定式记录，但Microwire-CMOS架构非常适合临床翻译。因此，该演示有助于为未来的高数据率皮质内植入铺平道路。
Decoding neural activity has been limited by the lack of tools available to record from large numbers of neurons across multiple cortical regions simultaneously with high temporal fidelity. To this end, we developed the Argo system to record cortical neural activity at high data rates. Here we demonstrate a massively parallel neural recording system based on platinum-iridium microwire electrode arrays bonded to a CMOS voltage amplifier array. The Argo system is the highest channel count in vivo neural recording system, supporting simultaneous recording from 65,536 channels, sampled at 32 kHz and 12-bit resolution. This system was designed for cortical recordings, compatible with both penetrating and surface microelectrodes. We validated this system through initial bench testing to determine specific gain and noise characteristics of bonded microwires, followed by in-vivo experiments in both rat and sheep cortex. We recorded spiking activity from 791 neurons in rats and surface LFP activity from over 30,000 channels in sheep. These are the largest channel count microwire-based recordings in both rat and sheep. While currently adapted for head-fixed recording, the microwire-CMOS architecture is well suited for clinical translation. Thus, this demonstration helps pave the way for a future high data rate intracortical implant.
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影响因子：
16.2
作者：
Hormuzdi, SG;Pais, I;Monyer, H
通讯作者：
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通讯作者：
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