Layer-by-layer nanoparticles with a pH-sheddable layer for in vivo targeting of tumor hypoxia.
Layer-by-layer nanoparticles with a pH-sheddable layer for in vivo targeting of tumor hypoxia.
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DOI：
10.1021/nn200876f
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发表时间：
2011-06-28
期刊：
影响因子：
17.1
通讯作者：
Hammond PT
中科院分区：
文献类型：
--
作者：
Poon Z;Chang D;Zhao X;Hammond PT
受到层层（LbL）组装的简单性和多功能性的启发，我们在纳米颗粒上应用多层聚电解质组装体，以创建可行的全身输送系统。专注于肿瘤特异性递送，具有 pH 敏感外隐形层的 LbL 纳米颗粒被证明可以靶向并保留在缺氧肿瘤区域。中性层因酸度而脱落，露出带电的纳米颗粒表面，很容易被肿瘤细胞吸收。首次在体内演示了这种靶向机制，并对纳米颗粒的摄取机制进行了初步检查。我们进一步证明，这种肿瘤靶向概念可能对多种癌症有效，适用于针对缺氧肿瘤组织的治疗。
Inspired by the simplicity and versatility of layer-by-layer (LbL) assembly, we apply multilayered polyelectrolyte assemblies on nanoparticles to create viable systemic delivery systems. Focusing on tumor specific delivery, LbL nanoparticles that exhibit a pH sensitive outer stealth layer are demonstrated to target and be retained in hypoxic tumor regions. The neutral layers shed in response to acidity to reveal a charged nanoparticle surface that is readily taken up by tumor cells. The first in vivo demonstration of this mechanism of targeting is presented, as well as an initial examination of mechanism of uptake of the nanoparticles. We further demonstrate that this concept for tumor targeting is potentially valid for a broad range of cancers, with applicability for therapies that target hypoxic tumor tissue.
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影响因子：
4.9
作者：
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通讯作者：
Farokhzad OC
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