Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography.
Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography.
复制标题
DOI：
10.1167/iovs.09-3817
复制
发表时间：
2010-04
影响因子：
4.4
通讯作者：
Schmidt-Erfurth U
中科院分区：
文献类型：
--
作者：
Ahlers C;Götzinger E;Pircher M;Golbaz I;Prager F;Schütze C;Baumann B;Hitzenberger CK;Schmidt-Erfurth U
光谱域光学相干断层扫描（SD-OCT）提供了新的见解，了解年龄相关性黄斑变性（AMD），但有限的信息，在视网膜色素上皮细胞水平的高反射组织的性质。因此，使用偏振敏感（PS）SD-OCT来识别和表征AMD中的典型RPE发现。44例AMD患者的44只眼被纳入该前瞻性病例系列，代表了从玻璃疣（n = 11）、地图状萎缩（GA; n = 11）、新生血管性AMD（nAMD; n = 11）到纤维化瘢痕（n = 11）的整个AMD谱。成像系统用于比较成像。开发了一种能够在单次扫描期间同时记录强度和偏振参数的PS-SD-OCT仪器。在玻璃疣中，PS-SD-OCT识别出具有局灶性隆起的连续RPE层。2例患者可观察到离散的RPE萎缩（RA）。在GA中，RA的延伸明显更大。在萎缩带内可检测到残留的RPE岛。PS-SD-OCT识别了nAMD患者的多个RPE损失病灶，并允许识别与脉络膜新生血管相关的晚期RPE疾病。在纤维化瘢痕中可以识别出含有完整视网膜色素上皮残留斑点的广泛RA区域。PS-SD-OCT提供了AMD中视网膜色素上皮的精确鉴定。在干性和湿性AMD中识别这些疾病特异性RA模式对于识别RPE疾病的状态和进展特别相关，并且可能有助于更好地估计AMD的功能预后。
Spectral-domain optical coherence tomography (SD-OCT) provides new insights into the understanding of age-related macular degeneration (AMD) but limited information on the nature of hyperreflective tissue at the level of the retinal pigment epithelium. Therefore, polarization-sensitive (PS) SD-OCT was used to identify and characterize typical RPE findings in AMD. Forty-four eyes of 44 patients with AMD were included in this prospective case series representing the entire AMD spectrum from drusen (n = 11), geographic atrophy (GA; n = 11), neovascular AMD (nAMD; n = 11) to fibrotic scars (n = 11). Imaging systems were used for comparative imaging. A PS-SD-OCT instrument was developed that was capable of recording intensity and polarization parameters simultaneously during a single scan. In drusen, PS-SD-OCT identified a continuous RPE layer with focal elevations. Discrete RPE atrophy (RA) could be observed in two patients. In GA, the extension of the RA was significantly larger. Residual RPE islands could be detected within the atrophic zone. PS-SD-OCT identified multiple foci of RPE loss in patients with nAMD and allowed recognition of advanced RPE disease associated with choroidal neovascularization. Wide areas of RA containing residual spots of intact retinal pigment epithelium could be identified in fibrotic scars. PS-SD-OCT provided precise identification of retinal pigment epithelium in AMD. Recognition of these disease-specific RA patterns in dry and wet forms of AMD is of particular relevance to identify the status and progression of RPE disease and may help to better estimate the functional prognosis of AMD.
登录
查看更多内容
影响因子：
13.7
作者：
Coleman, Anne L.;Yu, Fei
通讯作者：
Yu, Fei
影响因子：
158.5
作者：
Rosenfeld, Philip J.;Brown, David M.;Kim, Robert Y.
通讯作者：
Kim, Robert Y.
影响因子：
13.7
作者：
Ahlers, Christian;Golbaz, Isabelle;Schmidt-Erfurth, Ursula
通讯作者：
Schmidt-Erfurth, Ursula
影响因子：
3.8
作者：
Götzinger E;Pircher M;Geitzenauer W;Ahlers C;Baumann B;Michels S;Schmidt-Erfurth U;Hitzenberger CK
通讯作者：
Hitzenberger CK
人类视网膜的高速谱域偏振敏感光学相干断层扫描。
影响因子：
3.8
作者：
Götzinger E;Pircher M;Hitzenberger CK
通讯作者：
Hitzenberger CK