Plasma Membrane Receptors Involved in the Binding and Response of Osteoclasts to Noncellular Components of the Bone.
Plasma Membrane Receptors Involved in the Binding and Response of Osteoclasts to Noncellular Components of the Bone.
复制标题
质膜受体参与破骨细胞与骨骼非细胞成分的结合和反应。
DOI：
10.3390/ijms221810097
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发表时间：
2021-09-18
影响因子：
5.6
通讯作者：
Holliday LS
中科院分区：
文献类型：
--
作者：
Karanth DS;Martin ML;Holliday LS
破骨细胞从造血细胞分化而来，并响应于各种信号而吸收骨，其中一些信号直接来自骨的非细胞成分。在体外，粘附到骨触发破骨细胞之间的细胞-细胞融合事件的减少和破骨细胞的活化，以形成降解骨所需的不寻常的动态细胞骨架和膜结构。已知破骨细胞表面的整合素接收来自骨基质的调节信号。这些信号的可用性的调节是通过蛋白酶活性和磷酸化/去磷酸化事件对骨基质的酶促改变来实现的。其他膜受体存在于破骨细胞中，并可能与骨骼中尚未识别的信号相互作用。骨矿物质对破骨细胞具有调节作用，破骨细胞活性也直接受机械应力的调节。随着对破骨细胞和其他骨细胞如何与骨相互作用的理解的出现，已经做出越来越复杂的努力来创建骨仿生学，其再现骨的结构特性和骨调节破骨细胞和其他骨细胞的能力。对破骨细胞和骨之间相互作用的更全面的了解可能会导致治疗骨疾病和生产骨仿生修复缺损的新策略。
Osteoclasts differentiate from hematopoietic cells and resorb the bone in response to various signals, some of which are received directly from noncellular elements of the bone. In vitro, adherence to the bone triggers the reduction of cell–cell fusion events between osteoclasts and the activation of osteoclasts to form unusual dynamic cytoskeletal and membrane structures that are required for degrading the bone. Integrins on the surface of osteoclasts are known to receive regulatory signals from the bone matrix. Regulation of the availability of these signals is accomplished by enzymatic alterations of the bone matrix by protease activity and phosphorylation/dephosphorylation events. Other membrane receptors are present in osteoclasts and may interact with as yet unidentified signals in the bone. Bone mineral has been shown to have regulatory effects on osteoclasts, and osteoclast activity is also directly modulated by mechanical stress. As understanding of how osteoclasts and other bone cells interact with the bone has emerged, increasingly sophisticated efforts have been made to create bone biomimetics that reproduce both the structural properties of the bone and the bone’s ability to regulate osteoclasts and other bone cells. A more complete understanding of the interactions between osteoclasts and the bone may lead to new strategies for the treatment of bone diseases and the production of bone biomimetics to repair defects.
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影响因子：
--
作者：
Florencio-Silva R;Sasso GR;Sasso-Cerri E;Simões MJ;Cerri PS
通讯作者：
Cerri PS
影响因子：
4
作者：
de Vries, TJ;Schoenmaker, T;Everts, V
通讯作者：
Everts, V
影响因子：
12.7
作者：
Bartelt A;Behler-Janbeck F;Beil FT;Koehne T;Müller B;Schmidt T;Heine M;Ochs L;Yilmaz T;Dietrich M;Tuckermann JP;Amling M;Herz J;Schinke T;Heeren J;Niemeier A
通讯作者：
Niemeier A
影响因子：
3.3
作者：
Destaing, O;Saltel, F;Bard, F
通讯作者：
Bard, F
DOI：
10.1111/j.1749-6632.1995.tb44635.x
发表时间：
1995-01-01
期刊：
OSTEOPONTIN: ROLE IN CELL SIGNALLING AND ADHESION
影响因子：
--
作者：
BOSKEY, AL
通讯作者：
BOSKEY, AL