Neonatal Selenoenzyme Expression Is Variably Susceptible to Duration of Maternal Selenium Deficiency.
Neonatal Selenoenzyme Expression Is Variably Susceptible to Duration of Maternal Selenium Deficiency.
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DOI：
10.3390/antiox10020288
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发表时间：
2021-02-14
期刊：
影响因子：
--
通讯作者：
Nozik-Grayck E
中科院分区：
文献类型：
--
作者：
Sherlock LG;Balasubramaniyan D;Zheng L;Zarate M;Sizemore T;Delaney C;Tipple TE;Wright CJ;Nozik-Grayck E
母亲硒（Se）缺乏与新生儿硒水平降低有关，这增加了新生儿发病的风险。成年啮齿类动物缺硒后硒蛋白的表达有一个层次，这取决于特定的蛋白质和器官评估。然而，它是未知的，如何在怀孕期间有限的硒供应影响新生儿硒蛋白的表达。我们使用硒缺乏的饮食诱导围产期硒缺乏症（SeD），开始2-4周前开始的繁殖和持续通过妊娠。新生儿血浆，肝脏，心脏，肾脏和肺收集出生当天和评估硒蛋白，硒加工所需的因素，和非硒含抗氧化酶（AOE）。母亲硒降低新生儿循环和肝脏谷胱甘肽过氧化物酶（GPx）的活性，以及肝表达的Gpx 1和硒磷酸合成酶2（Sps 2）。相反，母亲硒对肝脏硫氧还蛋白还原酶1，肝脏非硒AOE，以及心脏，肾脏和肺GPx活性的影响，根据母亲暴露于硒饮食的持续时间而变化。我们的结论是，新生儿肝脏和循环表明母亲SeD后硒酶活性较早耗尽。我们的数据表明，延长母体SeD可能会通过逐步减少多个器官中的含硒AOE来增加新生儿的风险。
Maternal selenium (Se) deficiency is associated with decreased neonatal Se levels, which increases the risk for neonatal morbidities. There is a hierarchy to selenoprotein expression after Se deficiency in adult rodents, depending on the particular protein and organ evaluated. However, it is unknown how limited Se supply during pregnancy impacts neonatal selenoprotein expression. We used an Se-deficient diet to induce perinatal Se deficiency (SeD), initiated 2–4 weeks before onset of breeding and continuing through gestation. Neonatal plasma, liver, heart, kidney, and lung were collected on the day of birth and assessed for selenoproteins, factors required for Se processing, and non-Se containing antioxidant enzymes (AOE). Maternal SeD reduced neonatal circulating and hepatic glutathione peroxidase (GPx) activity, as well as hepatic expression of Gpx1 and selenophosphate synthetase 2 (Sps2). In contrast, the impact of maternal SeD on hepatic thioredoxin reductase 1, hepatic non-Se containing AOEs, as well as cardiac, renal, and pulmonary GPx activity, varied based on duration of maternal exposure to SeD diet. We conclude that the neonatal liver and circulation demonstrate earlier depletion in selenoenzyme activity after maternal SeD. Our data indicate that prolonged maternal SeD may escalate risk to the neonate by progressively diminishing Se-containing AOE across multiple organs.
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影响因子：
5.9
作者：
Arigliani M;Spinelli AM;Liguoro I;Cogo P
通讯作者：
Cogo P
影响因子：
26.1
作者：
Brumbaugh, Jane E.;Hansen, Nellie I.;Romano, Elaine
通讯作者：
Romano, Elaine
影响因子：
5.6
作者：
Hadley, KB;Sunde, RA
通讯作者：
Sunde, RA
影响因子：
4.8
作者：
Burk, Raymond F.;Olson, Gary E.;Kurokawa, Suguru
通讯作者：
Kurokawa, Suguru
DOI：
10.1006/bbrc.1997.6618
发表时间：
1997-05-19
影响因子：
3.1
作者：
Hill, KE;McCollum, GW;Burk, RF
通讯作者：
Burk, RF