An intelligent nanoplatform for imaging-guided photodynamic/photothermal/chemo-therapy based on upconversion nanoparticles and CuS integrated black phosphorus
An intelligent nanoplatform for imaging-guided photodynamic/photothermal/chemo-therapy based on upconversion nanoparticles and CuS integrated black phosphorus
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基于上转换纳米颗粒和 CuS 集成黑磷的成像引导光动力/光热/化疗智能纳米平台
DOI：
10.1016/j.cej.2019.122822
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发表时间：
2020-02
影响因子：
15.1
通讯作者：
Yang Piaoping
中科院分区：
文献类型：
--
作者：
Xu Mengshu;Yang Guixin;Bi Huiting;Xu Jiating;Dong Shuming;Jia Tao;Wang Zhao;Zhao Ruoxi;Sun Qianqian;Gai Shili;He Fei;Yang Dan;Yang Piaoping
影像学和治疗相结合的策略已被证明是一种广泛研究和有前途的方法。在这项工作中，我们首先集成了硫化铜（CuS）纳米粒子和黑磷（BP）纳米片通过介孔二氧化硅包覆的上转换纳米粒子（UCNPs）的强负电荷。载阿霉素后可实现光热、光动力和化疗的协同治疗。该纳米复合材料在808 nm近红外（NIR）光下表现出优异的抗肿瘤效率，并且避免了常规紫外和可见（UV-vis）光的略低效率和有限的穿透深度。在该体系中，介孔二氧化硅的孔径和BP的大比表面积有利于实现高DOX负载量。此外，由DOX释放引起的红色/绿色（R/G）比率的降低可用于确定通过荧光共振能量转移（FRET）过程的DOX释放的程度。通过掺杂稀土离子诱导的CT/MR成像赋予纳米系统在808 nm光照射下的多模成像能力，从而实现成像引导的癌症治疗。
The strategy of combining imaging and treatment has been shown as a widely studied and promising approach. In this work, we first integrated copper sulfide (CuS) nanoparticles and black phosphorus (BP) nanosheets with strong negative charges via mesoporous silica-coated upconversion nanoparticles (UCNPs). Synergistic treatment of photothermal, photodynamic and chemotherapy can be achieved after loading doxorubicin (DOX). The nanocomposites perform excellent antitumor efficiency under 808 nm near-infrared (NIR) light, and avoid the slightly lower efficiency and limited penetration depth of conventional ultraviolet and visible (UV–vis) light. In this system, the pore size of mesoporous silica and the large specific surface area of BP are advantageous for achieving high DOX loading capacity. Furthermore, the reduction in the red/green (R/G) ratio elicited by DOX release can be employed to determine the extent of DOX release by the fluorescence resonance energy transfer (FRET) process. CT/MR imaging induced by doping of rare earth ions imparts multimode imaging capabilities to nanosystem under 808 nm light irradiation, thereby enabling imaging-guided cancer treatment.
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