Reconstructing the somatotopic organization of the corticospinal tract remains a challenge for modern tractography methods.
Reconstructing the somatotopic organization of the corticospinal tract remains a challenge for modern tractography methods.
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DOI：
10.1002/hbm.26497
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发表时间：
2023-12-01
影响因子：
4.8
通讯作者：
O'Donnell LJ
中科院分区：
文献类型：
--
作者：
He J;Zhang F;Pan Y;Feng Y;Rushmore J;Torio E;Rathi Y;Makris N;Kikinis R;Golby AJ;O'Donnell LJ
皮质脊髓束（CST）是人脑中至关重要的白色纤维束，能够控制身体的随意运动。CST表现出躯体位置组织，这意味着控制特定身体部位的运动神经元在CST内按顺序排列。扩散磁共振成像（MRI）纤维束成像越来越多地用于研究CST的解剖结构。然而，尽管在过去十年中纤维束成像算法取得了许多进展，但现代最先进的方法仍然面临挑战。在这项研究中，我们比较了六种广泛使用的纤维束成像方法重建CST及其躯体组织的性能。这些方法包括基于约束球面反卷积（CSD）的概率（iFOD 1）和确定性（SD-Stream）方法、无迹卡尔曼滤波（UKF）纤维束成像方法（包括多纤维（UKF 2 T）和单纤维（UKF 1 T）模型）、基于广义q采样成像（GQI）的确定性纤维束成像方法和TractSeg方法。我们通过将CST分为四个亚部，每个半球起源于初级运动皮层的腿，躯干，手和面部区域来调查CST躯体特征。使用来自人类连接组项目的扩散MRI数据（N = 100名受试者）进行定量和视觉比较。定量评价包括八个解剖分区的重建率，每个分区中流线的百分比，以及白色物质-灰质（WM-GM）界面的覆盖率。通过比较腿部、躯干、手部和面部区域的皮质体积在每个细分中的流线百分比，进一步评估CST躯体特征。总体而言，UKF 2 T具有最高的重建率和皮质覆盖率。这是唯一的方法与一个显着的正相关性之间的百分比流线在每个细分和相应的运动皮层的体积。然而，我们的实验结果表明，所有比较tractography方法都偏向于产生许多主干流线（范围从35.10%到71.66%的总流线跨方法）。此外，对于所有比较的纤维束成像方法，最大运动区域（面部）中的WM-GM界面的覆盖率通常较低（低于40%）。不同的纤维束成像方法给出了相互矛盾的结果，在每个细分的流线的百分比和相应的运动皮层的体积，表明一般没有明确的关系，并且重建CST躯体形态仍然是一个很大的挑战。总体而言，我们得出结论，虽然目前的纤维束成像方法在改善CST外侧投影重建的众所周知的挑战方面取得了进展，但执行全面CST重建的总体问题，包括外侧（手和面部区域）和内侧部分（腿部区域）的临床重要投影，仍然是弥散MRI纤维束成像的重要挑战。在这项研究中，我们比较了六种纤维束成像方法重建皮质脊髓束（CST）和它的躯体组织的性能。根据解剖测量结果，我们得出结论，进行全面的CST重建，包括外侧和内侧部分的整体问题，仍然是纤维束成像的一个重要挑战。
The corticospinal tract (CST) is a critically important white matter fiber tract in the human brain that enables control of voluntary movements of the body. The CST exhibits a somatotopic organization, which means that the motor neurons that control specific body parts are arranged in order within the CST. Diffusion magnetic resonance imaging (MRI) tractography is increasingly used to study the anatomy of the CST. However, despite many advances in tractography algorithms over the past decade, modern, state‐of‐the‐art methods still face challenges. In this study, we compare the performance of six widely used tractography methods for reconstructing the CST and its somatotopic organization. These methods include constrained spherical deconvolution (CSD) based probabilistic (iFOD1) and deterministic (SD‐Stream) methods, unscented Kalman filter (UKF) tractography methods including multi‐fiber (UKF2T) and single‐fiber (UKF1T) models, the generalized q‐sampling imaging (GQI) based deterministic tractography method, and the TractSeg method. We investigate CST somatotopy by dividing the CST into four subdivisions per hemisphere that originate in the leg, trunk, hand, and face areas of the primary motor cortex. A quantitative and visual comparison is performed using diffusion MRI data (N = 100 subjects) from the Human Connectome Project. Quantitative evaluations include the reconstruction rate of the eight anatomical subdivisions, the percentage of streamlines in each subdivision, and the coverage of the white matter–gray matter (WM–GM) interface. CST somatotopy is further evaluated by comparing the percentage of streamlines in each subdivision to the cortical volumes for the leg, trunk, hand, and face areas. Overall, UKF2T has the highest reconstruction rate and cortical coverage. It is the only method with a significant positive correlation between the percentage of streamlines in each subdivision and the volume of the corresponding motor cortex. However, our experimental results show that all compared tractography methods are biased toward generating many trunk streamlines (ranging from 35.10% to 71.66% of total streamlines across methods). Furthermore, the coverage of the WM–GM interface in the largest motor area (face) is generally low (under 40%) for all compared tractography methods. Different tractography methods give conflicting results regarding the percentage of streamlines in each subdivision and the volume of the corresponding motor cortex, indicating that there is generally no clear relationship, and that reconstruction of CST somatotopy is still a large challenge. Overall, we conclude that while current tractography methods have made progress toward the well‐known challenge of improving the reconstruction of the lateral projections of the CST, the overall problem of performing a comprehensive CST reconstruction, including clinically important projections in the lateral (hand and face areas) and medial portions (leg area), remains an important challenge for diffusion MRI tractography. In this study, we compare the performance of six tractography methods for reconstructing the corticospinal tract (CST) and its somatotopic organization. Based on anatomical measurement results, we conclude that the overall problem of performing a comprehensive CST reconstruction, including both lateral and medial portions, remains an important challenge for tractography.
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影响因子：
5.7
作者：
Barakovic M;Tax CMW;Rudrapatna U;Chamberland M;Rafael-Patino J;Granziera C;Thiran JP;Daducci A;Canales-Rodríguez EJ;Jones DK
通讯作者：
Jones DK
局灶性癫痫中的纤维球白质建模。
影响因子：
4.8
作者：
Bryant L;McKinnon ET;Taylor JA;Jensen JH;Bonilha L;de Bezenac C;Kreilkamp BAK;Adan G;Wieshmann UC;Biswas S;Marson AG;Keller SS
通讯作者：
Keller SS
影响因子：
4.2
作者：
Bucci, Monica;Mandelli, Maria Luisa;Berman, Jeffrey I.;Amirbekian, Bagrat;Nguyen, Christopher;Berger, Mitchel S.;Henry, Roland G.
通讯作者：
Henry, Roland G.
DOI：
10.1016/j.nicl.2017.07.020
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Cousineau M;Jodoin PM;Morency FC;Rozanski V;Grand'Maison M;Bedell BJ;Descoteaux M
通讯作者：
Descoteaux M
影响因子：
4.8
作者：
Park JK;Kim BS;Choi G;Kim SH;Choi JC;Khang H
通讯作者：
Khang H